Preparation of heterocyclic compounds by reaction of dimethyl and diethyl acetylene dicarboxylate (DMAD, DEAD) with thiosemicarbazone derivatives

被引：49

作者：

Darehkordi, Ali

Saidi, Kazem ^{[1
]}

Islami, Mohammad Reza

机构：

[1] Shahid Bahonar Univ Kerman, Dept Chem, Kerman 76169, Iran

[2] Vali E Asr Univ Rafsanjan, Dept Chem, Rafsanjan, Iran

来源：

ARKIVOC | 2007年

关键词：

thiosemicarbazone; dimethyl acetylene dicarboxylate; diethyl acetylene dicarboxylate; thiazoline;

D O I：

10.3998/ark.5550190.0008.120

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Different thiosemicarbazone derivatives react with dimethyl acetylene dicarboxylate ( DMAD) and diethyl acetylene dicarboxylate ( DEAD) by three different methods: a) in ethyl acetate solvent at ambient temperature, b) one- pot synthesis under microwave irradiation and solvent-free conditions ( three- component reaction between thiosemicarbazide, aldehyde/ ketone and DMAD or DEAD), c) a microwave- assisted synthesis under solvent- free conditions, to obtain five- membered S, N- heterocycles thiazolines in good to excellent yields.

引用

页码：180 / 188

页数：9

共 8 条

[1]

Acheson R. M., 1981, J CHEM SOC P1, V2, P415

[2] Synthesis of novel thiazolidin-4-ones by reaction of malonthioamide derivatives with dimethyl acetylenedicarboxylate [J].