Association Between Gait Speed With Mortality, Cardiovascular Disease and Cancer: A Systematic Review and Meta-analysis of Prospective Cohort Studies

被引：158

作者：

Veronese, Nicola ^{[1
,2
]}

Stubbs, Brendon ^{[3
,4
,5
]}

Volpato, Stefano ^{[6
]}

Zuliani, Giovanni ^{[6
]}

Maggi, Stefania ^{[1
]}

Cesari, Matteo ^{[7
]}

Lipnicki, Darren M. ^{[8
]}

Smith, Lee ^{[5
]}

Schofield, Patricia ^{[5
]}

Firth, Joseph ^{[9
,10
]}

Vancampfort, Davy ^{[11
,12
]}

Koyanagi, Ai ^{[13
,14
]}

Pilotto, Alberto ^{[2
]}

Cereda, Emanuele ^{[15
]}

机构：

[1] CNR, Inst Neurosci, Aging Branch, Padua, Italy

[2] Natl Relevance & High Specializat Hosp, Ente Osped Galliera Hosp, Dept Geriatr Care OrthoGeriatr & Rehabil, Geriatr Unit, Genoa, Italy

[3] South London & Maudsley NHS Fdn Trust, Physiotherapy Dept, Denmark Hill, London, England

[4] Kings Coll London, Inst Psychiat, Dept Psychol Med, De Crespigny Pk, London, England

[5] Anglia Ruskin Univ, Bishop Hall Lane, Chelmsford, Essex, England

[6] Univ Ferrara, Dept Med Sci, Ferrara, Italy

[7] Univ Milan, Fdn IRCCS Ca Granda Osped Maggiore Policlin, Milan, Italy

[8] UNSW Med, Sch Psychiat, Sydney, NSW, Australia

[9] Univ Western Sydney, Sch Sci & Hlth, NICM, Sydney, NSW, Australia

[10] Univ Manchester, Div Psychol & Mental Hlth, Manchester, Lancs, England

[11] Katholieke Univ Leuven, Dept Rehabil Sci, Leuven, Kortenberg, Belgium

[12] Katholieke Univ Leuven, Univ Psychiat Ctr, Leuven, Kortenberg, Belgium

[13] Univ Barcelona, Res & Dev Unit, Parc Sanitari St Joan de Deu, Barcelona, Spain

[14] Inst Salud Carlos III, CIBERSAM, Ctr Invest Biomed Red Salud Mental, Madrid, Spain

[15] Fdn IRCCS Policlin San Matteo, Clin Nutr & Dietet Unit, Pavia, Italy

来源：

JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION | 2018年 / 19卷 / 11期

关键词：

Gait speed; mortality; cardiovascular disease; cancer; meta-analysis; ALL-CAUSE MORTALITY; PHYSICAL PERFORMANCE; WALKING SPEED; OLDER-ADULTS; FUNCTIONAL STATUS; PROGNOSTIC VALUE; HEART-FAILURE; RISK; HEALTH; SURVIVAL;

D O I：

10.1016/j.jamda.2018.06.007

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Objectives: Slow gait speed may be associated with premature mortality, cardiovascular disease (CVD), and cancer, although a comprehensive meta-analysis is lacking. In this systematic review and metaanalysis, we explored potential associations between gait speed and mortality, incident CVD, and cancer. Design: A systematic search in major databases was undertaken from inception until March 15, 2018 for prospective cohort studies reporting data on gait speed and mortality, incident CVD, and cancer. Setting and Participants: All available. Measures: The adjusted hazard ratios (HRs) and 95% confidence intervals (CIs), based on the model with the maximum number of covariates for each study between gait speed (categorized as decrease in 0.1 m/s) and mortality, incident CVD, and cancer, were meta-analyzed with a random effects model. Results: Among 7026 articles, 44 articles corresponding to 48 independent cohorts were eligible. The studies followed up on a total of 101,945 participants (mean age 72.2 years; 55% women) for a median of 5.4 years. After adjusting for a median of 9 potential confounders and the presence of publication bias, each reduction of 0.1 m/s in gait speed was associated with a 12% increased risk of earlier mortality (45 studies; HR = 1.12, 95% CI: 1.09-1.14; I-2 = 90%) and 8% increased risk of CVD (13 studies; HR = 1.08, 95% CI: 1.03-1.13; I-2 = 81%), but no relationship with cancer was observed (HR = 1.00, 95% CI: 0.97-1.04; I-2 = 15%). Conclusion/implications: Slow gait speed may be a predictor of mortality and CVD in older adults. Because gait speed is a quick and inexpensive measure to obtain, our study suggests that it should be routinely used and may help identify people at risk of premature mortality and CVD. (C) 2018 AMDA - The Society for Post-Acute and Long-Term Care Medicine.

引用

页码：981 / +

页数：15

共 85 条

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