The Effects of Ellagic Acid upon Brain Cells: A Mechanistic View and Future Directions

被引：52
作者：
de Oliveira, Marcos Roberto [1 ]
机构：
[1] Fed Univ Mato Grosso UFMT, Postgrad Program Chem PPGQ, Dept Chem ICET, Av Fernando Correa da Costa 2367, BR-78060900 Cuiaba, MT, Brazil
来源：
NEUROCHEMICAL RESEARCH | 2016年 / 41卷 / 06期
关键词：
Ellagic acid; Neuron; Glia; Brain; Antioxidant; NF-KAPPA-B; LONG-TERM POTENTIATION; MANGANESE SUPEROXIDE-DISMUTASE; DIETARY PHENOLIC-COMPOUNDS; DRUG-DELIVERY-SYSTEM; RAT DENTATE GYRUS; IN-VITRO; OXIDATIVE STRESS; NEUROBLASTOMA-CELLS; POMEGRANATE JUICE;
D O I：
10.1007/s11064-016-1853-9
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Ellagic acid (EA, 2,3,7,8-tetrahydroxy-chromeno; C14H6O8) is a polyphenol derived from fruits (pomegranates, berries) and nuts. EA exhibits antioxidant capacity and induces anti-inflammatory actions in several mammalian tissues. EA has been characterized as a possible neuroprotective agent, but the number of reports is still limited to conclude whether and how EA exerts neuroprotection in humans. In this regard, performing additional studies considering the potential beneficial and/or toxicological roles for EA on brain cells would be an important step towards fully understanding of when and how EA may be securely utilized by humans as a neuroprotective agent. The aim of the present work is to discuss data related to the neuronal and glial effects of EA and the mechanisms underlying such events. Moreover, future directions are suggested as a potential guide to be utilized by researchers interested in investigating the neuronal and glial actions of EA hereafter.
引用
收藏
页码：1219 / 1228
页数：10
相关论文
共 112 条
[41]   Development of Chitosan-Ellagic Acid Films as a Local Drug Delivery System to Induce Apoptotic Death of Human Melanoma Cells [J].
Kim, Sungwoo ;
Liu, Yongxing ;
Gaber, M. Waleed ;
Bumgardner, Joel D. ;
Haggard, Warren O. ;
Yang, Yunzhi .
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, 2009, 90B (01) :145-155
[42]   DYSTONIA AND TREMOR FOLLOWING EXPOSURE TO 2,3,7,8-TETRACHLORODIBENZO-PARA-DIOXIN [J].
KLAWANS, HL .
MOVEMENT DISORDERS, 1987, 2 (04) :255-261
[43]   Effects of Nicorandil in Neuroprotective Activation of PI3K/AKT Pathways in a Cellular Model of Alzheimer's Disease [J].
Kong, Jingjing ;
Ren, Guiru ;
Jia, Ning ;
Wang, Yanfu ;
Zhang, Hua ;
Zhang, Wei ;
Chen, Bingkun ;
Cao, Yunpeng .
EUROPEAN NEUROLOGY, 2013, 70 (3-4) :233-241
[44]   INVOLVEMENT OF THE Nrf2/HO-1 SIGNALING PATHWAY IN SULFURETIN-INDUCED PROTECTION AGAINST AMYLOID BETA25-35 NEUROTOXICITY [J].
Kwon, S. -H. ;
Ma, S. -X. ;
Hwang, J. -Y. ;
Lee, S. -Y. ;
Jang, C. -G. .
NEUROSCIENCE, 2015, 304 :14-28
[45]  
LASORELLA A, 1995, CANCER RES, V55, P4711
[46]   N-acylated chitosan:: hydrophobic matrices for controlled drug release [J].
Le Tien, C ;
Lacroix, M ;
Ispas-Szabo, P ;
Mateescu, MA .
JOURNAL OF CONTROLLED RELEASE, 2003, 93 (01) :1-13
[47]   Protective Effect of Ellagic Acid on Concanavalin A-Induced Hepatitis via Toll-Like Receptor and Mitogen-Activated Protein Kinase/Nuclear Factor KB Signaling Pathways [J].
Lee, Jae Hong ;
Won, Jong Hoon ;
Choi, Jong Min ;
Cha, Hye Hyeon ;
Jang, Yeo Jin ;
Park, Seohyeon ;
Kim, Han Gyeol ;
Kim, Hyung Ch-Ul ;
Kim, Dae Kyong .
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2014, 62 (41) :10110-10117
[48]   Ellagic acid inhibits oxidized LDL-mediated LOX-1 expression, ROS generation, and inflammation in human endothelial cells [J].
Lee, Wen-Jane ;
Ou, Hsiu-Chung ;
Hsu, Wen-Cheng ;
Chou, Min-Min ;
Tseng, Jenn-Jhy ;
Hsu, Shih-Lan ;
Tsai, Kun-Ling ;
Sheu, Wayne Huey-Herng .
JOURNAL OF VASCULAR SURGERY, 2010, 52 (05) :1290-1300
[49]   Pharmacokinetic study of ellagic acid in rat after oral administration of pomegranate leaf extract [J].
Lei, F ;
Xing, DM ;
Xiang, L ;
Zhao, YN ;
Wang, W ;
Zhang, LJ ;
Du, LJ .
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2003, 796 (01) :189-194
[50]   Neuroglobin Attenuates Beta Amyloid-Induced Apoptosis Through Inhibiting Caspases Activity by Activating PI3K/Akt Signaling Pathway [J].
Li, Yu ;
Dai, Yu-bing ;
Sun, Jie-yun ;
Xiang, Yue ;
Yang, Jun ;
Dai, Song-yang ;
Zhang, Xiong .
JOURNAL OF MOLECULAR NEUROSCIENCE, 2016, 58 (01) :28-38
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