The Effects of Ellagic Acid upon Brain Cells: A Mechanistic View and Future Directions

被引：52
作者：
de Oliveira, Marcos Roberto [1 ]
机构：
[1] Fed Univ Mato Grosso UFMT, Postgrad Program Chem PPGQ, Dept Chem ICET, Av Fernando Correa da Costa 2367, BR-78060900 Cuiaba, MT, Brazil
来源：
NEUROCHEMICAL RESEARCH | 2016年 / 41卷 / 06期
关键词：
Ellagic acid; Neuron; Glia; Brain; Antioxidant; NF-KAPPA-B; LONG-TERM POTENTIATION; MANGANESE SUPEROXIDE-DISMUTASE; DIETARY PHENOLIC-COMPOUNDS; DRUG-DELIVERY-SYSTEM; RAT DENTATE GYRUS; IN-VITRO; OXIDATIVE STRESS; NEUROBLASTOMA-CELLS; POMEGRANATE JUICE;
D O I：
10.1007/s11064-016-1853-9
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Ellagic acid (EA, 2,3,7,8-tetrahydroxy-chromeno; C14H6O8) is a polyphenol derived from fruits (pomegranates, berries) and nuts. EA exhibits antioxidant capacity and induces anti-inflammatory actions in several mammalian tissues. EA has been characterized as a possible neuroprotective agent, but the number of reports is still limited to conclude whether and how EA exerts neuroprotection in humans. In this regard, performing additional studies considering the potential beneficial and/or toxicological roles for EA on brain cells would be an important step towards fully understanding of when and how EA may be securely utilized by humans as a neuroprotective agent. The aim of the present work is to discuss data related to the neuronal and glial effects of EA and the mechanisms underlying such events. Moreover, future directions are suggested as a potential guide to be utilized by researchers interested in investigating the neuronal and glial actions of EA hereafter.
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收藏
页码：1219 / 1228
页数：10
相关论文
共 112 条
[1]   Ellagic acid, an NF-κB inhibitor, ameliorates renal function in experimental diabetic nephropathy [J].
Ahad, Amjid ;
Ganai, Ajaz Ahmad ;
Mujeeb, Mohd ;
Siddiqui, Waseem Ahmad .
CHEMICO-BIOLOGICAL INTERACTIONS, 2014, 219 :64-75
[2]   Pomegranate extract protects against cerebral ischemia/reperfusion injury and preserves brain DNA integrity in rats [J].
Ahmed, Maha A. E. ;
El Morsy, Engy M. ;
Ahmed, Amany A. E. .
LIFE SCIENCES, 2014, 110 (02) :61-69
[3]   Ellagic acid ameliorates nickel induced biochemical alterations: diminution of oxidative stress [J].
Ahmed, S ;
Rahman, A ;
Saleem, M ;
Athar, M ;
Sultana, S .
HUMAN & EXPERIMENTAL TOXICOLOGY, 1999, 18 (11) :691-698
[4]   Altered sensitivity to ellagic acid in neuroblastoma cells undergoing differentiation with 12-O-tetradecanoylphorbol-13-acetate and all-trans retinoic acid [J].
Alfredsson, Christina Fjaeraa ;
Rendel, Filip ;
Liang, Qui-Li ;
Sundstrom, Birgitta E. ;
Nanberg, Eewa .
BIOMEDICINE & PHARMACOTHERAPY, 2015, 76 :39-45
[5]   Ellagic acid induces a dose- and time-dependent depolarization of mitochondria and activation of caspase-9 and-3 in human neuroblastoma cells [J].
Alfredsson, Christina Fjaeraa ;
Ding, Menglei ;
Liang, Qiu-Li ;
Sundstrom, Birgitta E. ;
Nanberg, Eewa .
BIOMEDICINE & PHARMACOTHERAPY, 2014, 68 (01) :129-135
[6]   Dietary supplementation of an ellagic acid-enriched pomegranate extract attenuates chronic colonic inflammation in rats [J].
Angeles Rosillo, Maria ;
Sanchez-Hidalgo, Marina ;
Cardeno, Ana ;
Aparicio-Soto, Marina ;
Sanchez-Fidalgo, Susana ;
Villegas, Isabel ;
Alarcon-de-la-Lastra, Catalina .
PHARMACOLOGICAL RESEARCH, 2012, 66 (03) :235-242
[7]   Ellagic acid coordinately attenuates Wnt/β-catenin and NF-κB signaling pathways to induce intrinsic apoptosis in an animal model of oral oncogenesis [J].
Anitha, Prabukumar ;
Priyadarsini, Ramamurthi Vidya ;
Kavitha, Krishnamurthy ;
Thiyagarajan, Paranthaman ;
Nagini, Siddavaram .
EUROPEAN JOURNAL OF NUTRITION, 2013, 52 (01) :75-84
[8]  
[Anonymous], 2013, OXID MED CELL LONGEV, DOI DOI 10.1155/2013/685909
[9]   Ellagic acid encapsulated chitosan nanoparticles for drug delivery system in human oral cancer cell line (KB) [J].
Arulmozhi, V. ;
Pandian, K. ;
Mirunalini, S. .
COLLOIDS AND SURFACES B-BIOINTERFACES, 2013, 110 :313-320
[10]   RECEPTORS FOR INTERLEUKIN-1 (ALPHA AND BETA) IN MOUSE-BRAIN - MAPPING AND NEURONAL LOCALIZATION IN HIPPOCAMPUS [J].
BAN, E ;
MILON, G ;
PRUDHOMME, N ;
FILLION, G ;
HAOUR, F .
NEUROSCIENCE, 1991, 43 (01) :21-30
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