Mechanochemical N-alkylation of imides

被引：13

作者：

Bris, Anamarija ^{[1
]}

Dud, Mateja ^{[1
]}

Margetic, Davor ^{[1
]}

机构：

[1] Rudjer Boskovic Inst, Lab Phys Organ Chem, Div Organ Chem & Biochem, Bijenicka C 54, Zagreb 10000, Croatia

来源：

BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY | 2017年 / 13卷

关键词：

ball milling; Gabriel reaction; imides; mechanochemistry; N-alkylation; SOLID-STATE; BALL-MILL; MECHANOSYNTHESIS; DERIVATIVES;

D O I：

10.3762/bjoc.13.169

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The mechanochemical N-alkylation of imide derivatives was studied. Reactions under solvent-free conditions in a ball mill gave good yields and could be put in place of the classical solution conditions. The method is general and can be applied to various imides and alkyl halides. Phthalimides prepared under ball milling conditions were used in a mechanochemical Gabriel synthesis of amines by their reaction with 1,2-diaminoethane.

引用

收藏

页码：1745 / 1752

页数：8

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