Neurotherapeutic Effects of Pueraria mirifica Extract in Early- and Late-Stage Cognitive Impaired Rats

被引:26
作者
Anukulthanakorn, Kanya [1 ,2 ]
Parhar, Ishwar S. [3 ]
Jaroenporn, Sukanya [2 ]
Kitahashi, Takashi [3 ]
Watanbe, Gen [4 ]
Malaivijitnond, Suchinda [2 ]
机构
[1] Chulalongkorn Univ, Biol Sci Program, Fac Sci, Bangkok 10330, Thailand
[2] Chulalongkorn Univ, Dept Biol, Fac Sci, 254 Phayathai Rd, Bangkok 10330, Thailand
[3] Monash Univ Malaysia, Brain Res Inst, Jeffrey Cheah Sch Med & Hlth Sci, PJ46150, Bandar Sunway, Malaysia
[4] Tokyo Univ Agr & Technol, Vet Physiol Lab, Tokyo, Japan
关键词
Alzheimer's disease; amyloid plaques; estrogen receptor; menopause; neurofibrillary tangles; spatial memory; ESTROGEN REPLACEMENT THERAPY; PHYTOESTROGEN-RICH PLANT; ALZHEIMERS-DISEASE; POSTMENOPAUSAL WOMEN; LUTEINIZING-HORMONE; HIPPOCAMPAL-NEURONS; CONTROLLED-TRIAL; TRANSGENIC MICE; RECEPTOR-ALPHA; FEMALE RATS;
D O I
10.1002/ptr.5595
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
We determined the neurotherapeutic effects of Pueraria mirifica extract (PME) and pure puerarin (PU) in comparison with 17-estradiol (E-2) in early- and late-stage cognitive impaired rats. Rats were ovariectomized (OVX), kept for 2 and 4months to induce early- and late-stage cognitive impairment, respectively, and divided into four groups that were treated daily with (i) distilled water, (ii) 100mg/kg of PME, (iii) 7mg/kg of PU, and (iv) 80 mu g/kg of E-2 for 4months. The estrogen deficiency symptoms of OVX rats were abrogated by treatment with E-2 or PME, but not by treatment with PU. The mRNA level of genes associated with amyloid production (App and Bace1) and hyperphosphorylated Tau (Tau4) were upregulated together with the level of impaired cognition in the 2- and 4-month OVX rats. Treatment with E-2 reduced the level of cognitive impairment more than that with PME and PU, and 2-month OVX rats were more responsive than 4-month OVX rats. All treatments down-regulated the Bace1 mRNA level in 2-month OVX rats, while PU and PME also decreased the App mRNA level in 2- and 4-month OVX rats, respectively. Only PU suppressed Tau4 expression in 2-month OVX rats. Thus, PME and PU elicit neurotherapeutic effects in different pathways, and earlier treatment is optimal. Copyright (c) 2016 John Wiley & Sons, Ltd.
引用
收藏
页码:929 / 939
页数:11
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