Native SOCE complexes: Small but mighty?

被引：1

作者：

Courjaret, Raphael ^{[1
]}

Machaca, Khaled ^{[1
]}

机构：

[1] Weill Cornell Med Qatar, Dept Physiol & Biophys, Qatar Fdn, Ca2 Signaling Grp, POB 24144, Doha, Qatar

来源：

CELL CALCIUM | 2021年 / 97卷

关键词：

STIM1; Orai1; Store-operated calcium entry; CRISPR/CAS9; TIRF; Photobleaching; STIM;

D O I：

10.1016/j.ceca.2021.102421

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Our current understanding of the molecular mechanisms underlying activation of store-operated Ca2+ entry (SOCE) relies in large part on studies that modulate the expression of STIM1 and Orai1. Shen et al. present the first detailed study to address the dynamics and stoichiometry of endogenous STIM1 and Orai1. They argue for an active SOCE cluster centered around a single Orai1 channel per punctum linked to 12 STIM1 dimers, which could have significant implications on SOCE-dependent Ca2+ signaling.

引用

页数：3