Reactivity of 2-thiohydantoins towards various electrophilic reagents:: Applications to the synthesis of new 2-ylidene-3,5-dihydro-4H-imidazol-4-ones.

被引：35
作者：
Chérouvrier, JR
Carreaux, F
Bazureau, JP
机构：
[1] Univ Rennes 1, Inst Chim Synth & Electrosynth Organ 3, UMR 6510, F-35042 Rennes, France
[2] Univ Rennes 1, Inst Chim Organomet & Catalyse Chim & Electrochim, UMR 6509, F-35042 Rennes, France
来源：
MOLECULES | 2004年 / 9卷 / 10期
关键词：
thiohydantoins; ketene dithioacetal; dimethylformamide diethylacetal; microwave irradiation;
D O I：
10.3390/91000867
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A new route to 5-(imidazolidin-2-ylidene)-2-methylsulfanyl-3,5-dihydroimidazol-4-ones 4a-c using ketene dithioacetal intermediates 3a-c is described. The reactivity of thiohydantoin derivatives 2a-c towards N,N-dimethylformamide diethylacetal (DMF-DEA) was also explored using solvent-free technique under microwave irradiation (mu omega). The H-1- and C-13-NMR spectra of some representative products are discussed.
引用
收藏
页码：867 / 875
页数：9
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