Host variations in SARS-CoV-2 infection

被引：1

作者：

Altiok, Doruk ^{[1
]}

Savci, Elif Zeynep ^{[2
]}

Ozkara, Busra ^{[3
]}

Alkan, Kamil ^{[2
]}

Namdar, Dilara Sultan ^{[2
]}

Tuncer, Gizem ^{[4
,5
]}

Kilinc, Bugrahan Regaip ^{[6
,7
]}

Suicmez, Evren ^{[8
]}

Cetin, Guneysu ^{[9
]}

Unal, Sinan ^{[10
]}

Donmus, Beyza ^{[10
]}

Karagulleoglu, Zeynep Yagmur ^{[10
]}

Uncuoglu, Dilruba Beyza ^{[11
]}

Tekeli, Cansu ^{[12
]}

Mendi, Hanife Aysegul ^{[13
]}

Bengi, Vahdi Umut ^{[14
]}

Seval, Guldane Cengiz ^{[15
]}

Kilic, Pelin ^{[5
,16
]}

Altuntas, Evrim Gunes ^{[17
]}

Demir-Dora, Devrim ^{[18
,19
,20
]}

机构：

[1] Baskent Univ, Fac Dent, Ankara, Turkey

[2] Akdeniz Univ, Fac Med, Antalya, Turkey

[3] Suleyman Demirel Univ, Fac Med, Isparta, Turkey

[4] Hacettepe Univ, Grad Sch Sci & Engn, Gen Biol Program, Ankara, Turkey

[5] HucreCELL Biotechnol Dev & Commerce Inc, Ankara, Turkey

[6] Kastamonu Univ, Sch Engn & Architecture, Dept Genet & Bioengn, Kastamonu, Turkey

[7] Kastamonu Univ, Sch Engn & Architecture, Dept Biomed Engn, Kastamonu, Turkey

[8] Yildiz Tech Univ, Grad Sch Sci & Engn, Dept Mol Biol & Genet, Istanbul, Turkey

[9] Bilkent Univ, Fac Sci, Dept Mol Biol & Genet, Ankara, Turkey

[10] Yildiz Tech Univ, Fac Arts & Sci, Dept Mol Biol & Genet, Istanbul, Turkey

[11] Ankara Univ, Grad Sch Nat & Appl Sci, Dept Biol, Ankara, Turkey

[12] TOBB Univ Econ & Technol, Sch Engn, Dept Biomed Engn, Ankara, Turkey

[13] Gazi Univ, Fac Dent, Dept Basic Sci, Div Med Microbiol, Ankara, Turkey

[14] Gulhane Training & Res Hosp, Fac Dent, Dept Periodontol, Ankara, Turkey

[15] Ankara Univ, Sch Med Dept Hematol, Ankara, Turkey

[16] Ankara Univ, Stem Cell Inst, Ankara, Turkey

[17] Ankara Univ, Biotechnol Inst, Ankara, Turkey

[18] Akdeniz Univ, Fac Med, Dept Med Pharmacol, Antalya, Turkey

[19] Akdeniz Univ, Hlth Sci Inst, Dept Gene & Cell Therapy, Antalya, Turkey

[20] Akdeniz Univ, Hlth Sci Inst, Dept Med Biotechnol, Antalya, Turkey

来源：

TURKISH JOURNAL OF BIOLOGY | 2021年 / 45卷 / 04期

关键词：

Angiotensin-converting enzyme 2 (ACE2); host genetics; polymorphisms; SARS-CoV-2; toll-like receptors (TLR); transmembrane serine protease 2 (TMPRSS2); ACUTE RESPIRATORY SYNDROME; SARS-CORONAVIRUS PATHOGENESIS; DNA METHYLATION; PROSTATE-CANCER; PROMOTER POLYMORPHISM; GENE POLYMORPHISMS; SPIKE PROTEIN; BLOOD-GROUP; ACE2; SUSCEPTIBILITY;

D O I：

10.3906/biy-2104-67

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the zoonotic pathogen that causes the "Coronavirus Disease of 2019 (COVID-19)", and COVID-19 itself is yet to be thoroughly understood. Both the disease as well as the mechanisms by which the host interacts with the SARS-CoV-2 have not been fully enlightened. The epidemiological factors -e.g. age, sex, race-, the polymorphisms of the host proteins, the blood types and individual differences have all been in discussions about affecting the progression and the course of COVID-19 both individually and collectively, as their effects are mostly interwoven. We focused mainly on the effect of polymorphic variants of the host proteins that have been shown to take part in and/or affect the pathogenesis of COVID-19. Additionally, how the procedures of diagnosing and treating COVID-19 are affected by these variants and what possible changes can be implemented are the other questions, which are sought to be answered.

引用

页码：404 / 424

页数：21

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