Topical antibacterial agents for wound care: A primer

被引:43
作者
Spann, CT
Tutrone, WD
Weinberg, JM
Scheinfeld, N
Ross, B
机构
[1] St Lukes Roosevelt Hosp, Dept Dermatol, New York, NY 10025 USA
[2] Beth Israel Deaconess Med Ctr, New York, NY USA
关键词
D O I
10.1046/j.1524-4725.2003.29143.x
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Although often overlooked, topical antibiotic agents play an important role in dermatology. Their many uses include prophylaxis against cutaneous infections, treatment of minor wounds and infections, and elimination of nasal carriage of Stapylococcus aureus . For these indications, they are advantageous over their systemic counterparts because they deliver a higher concentration of medication directly to the desired area and are less frequently implicated in causing bacterial resistance. The ideal topical antibiotic has a broad spectrum of activity, has persistent antibacterial effects, and has minimal toxicity or incidence of allergy.
引用
收藏
页码:620 / 626
页数:7
相关论文
共 33 条
  • [1] SURGICAL PEARL - ERYTHROMYCIN OINTMENT FOR TOPICAL ANTIBIOTIC WOUND CARE
    BERNSTEIN, SC
    ROENIGK, RK
    [J]. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 1995, 32 (04) : 659 - 660
  • [2] Comaish J S, 1967, Br J Clin Pract, V21, P97
  • [3] An open study comparing topical silver sulfadiazine and topical silver sulfadiazine - cerium nitrate in the treatment of moderate and severe burns
    de Gracia, CG
    [J]. BURNS, 2001, 27 (01) : 67 - 74
  • [4] Haemophilus ducreyi is susceptible to protegrin
    Fortney, K
    Totten, PA
    Lehrer, RI
    Spinola, SM
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1998, 42 (10) : 2690 - 2693
  • [5] The expression of the gene coding for the antibacterial peptide LL-37 is induced in human keratinocytes during inflammatory disorders
    Frohm, M
    Agerberth, B
    Ahangari, G
    StahleBackdahl, M
    Liden, S
    Wigzell, H
    Gudmundsson, GH
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (24) : 15258 - 15263
  • [6] Ganz T, 1997, SEMIN HEMATOL, V34, P343
  • [7] In vitro antibacterial properties of pexiganan, an analog of magainin
    Ge, YG
    MacDonald, DL
    Holroyd, KJ
    Thornsberry, C
    Wexler, H
    Zasloff, M
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1999, 43 (04) : 782 - 788
  • [8] In vitro susceptibility to pexiganan of bacteria isolated from infected diabetic foot ulcers
    Ge, YG
    MacDonald, D
    Henry, MM
    Halt, HI
    Nelson, KA
    Lipsky, BA
    Zasloff, MA
    Holroyd, KJ
    [J]. DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, 1999, 35 (01) : 45 - 53
  • [9] Efficacy of a new cream formulation of mupirocin: Comparison with oral and topical agents in experimental skin infections
    Gisby, J
    Bryant, J
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2000, 44 (02) : 255 - 260
  • [10] Update on therapy of atopic dermatitis
    Hanifin, JM
    Tofte, SJ
    [J]. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1999, 104 (03) : S123 - S125