High-Risk Acute Myeloid Leukemia: A Pediatric Prospective

被引：2

作者：

Cacace, Fabiana ^{[1
]}

Iula, Rossella ^{[2
]}

De Novellis, Danilo ^{[3
]}

Caprioli, Valeria ^{[1
]}

D'Amico, Maria Rosaria ^{[1
]}

De Simone, Giuseppina ^{[1
]}

Cuccurullo, Rosanna ^{[4
]}

Wierda, William G. ^{[5
]}

Mahadeo, Kris Michael ^{[6
]}

Menna, Giuseppe ^{[4
]}

Tambaro, Francesco Paolo ^{[1
]}

机构：

[1] Azienda Osped Rilievo Nazl Santobono Pausilipon, Unita Operat Trapianto Cellule Staminali Ematopoi, I-80123 Naples, Italy

[2] Azienda Osped Univ Federico II, Dipartimento Med Clin & Chirurg, I-80100 Naples, Italy

[3] Osped San Giovanni Dio & Ruggi DAragona, Ctr Ematol & Trapianto, I-84131 Salerno, Italy

[4] Azienda Osped Rilievo Nazl Santobono Pausilipon, Unita Operat Ematol, I-80123 Naples, Italy

[5] Univ Texas MD Anderson Canc Ctr, Dept Leukemia, Houston, TX 77030 USA

[6] Univ Texas MD Anderson Canc Ctr, CARTOX Program, Pediat Stem Cell Transplantat & Cellular Therapy, Houston, TX 77030 USA

来源：

BIOMEDICINES | 2022年 / 10卷 / 06期

关键词：

AML; pediatric; risk stratification; outcome; target therapy; CHIMERIC ANTIGEN RECEPTOR; CONVENTIONAL CARE REGIMENS; ACUTE MYELOGENOUS LEUKEMIA; REFRACTORY SOLID TUMORS; STEM-CELL FACTOR; GEMTUZUMAB OZOGAMICIN; MYELODYSPLASTIC SYNDROMES; PROGNOSTIC-SIGNIFICANCE; OLDER PATIENTS; OPEN-LABEL;

D O I：

10.3390/biomedicines10061405

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Pediatric acute myeloid leukemia is a clonal disorder characterized by malignant transformation of the hematopoietic stem cell. The incidence and the outcome remain inferior when compared to pediatric ALL, although prognosis has improved in the last decades, with 80% overall survival rate reported in some studies. The standard therapeutic approach is a combined cytarabine and anthracycline-based regimen followed by consolidation with allogeneic stem cell transplantation (allo-SCT) for high-risk AML and allo-SCT for non-high-risk patients only in second complete remission after relapse. In the last decade, several drugs have been used in clinical trials to improve outcomes in pediatric AML treatment.

引用

页数：18

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