An efficient entry to 1,2-benzisoxazoles via 1,3-dipolar cycloaddition of in situ generated nitrile oxides and benzyne

被引：31

作者：

Spiteri, Christian ^{[1
,2
]}

Mason, Christopher ^{[1
]}

Zhang, Fengzhi ^{[1
]}

Ritson, Dougal J. ^{[1
]}

Sharma, Pallavi ^{[1
,2
]}

Keeling, Steve ^{[2
]}

Moses, John E. ^{[1
]}

机构：

[1] Univ Nottingham, Sch Chem, Nottingham NG7 2RD, England

[2] GlaxoSmithKline Inc, Med Res Ctr, Stevenage, Herts, England

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2010年 / 8卷 / 11期

基金：

英国工程与自然科学研究理事会;

关键词：

BASE-CATALYZED REARRANGEMENT; BOND FORMATION; DERIVATIVES; CHEMISTRY; OXIMES; INHIBITORS; POTENT; BENZISOXAZOLES; NUCLEOPHILES; DIMERIZATION;

D O I：

10.1039/b927235f

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient protocol for the synthesis of a range of 1,2-benzisoxazoles using an improved 1,3-dipolar cycloaddition of nitrile oxides and benzyne is described. Key to the procedure is the in situ generation of the reactive nitrile oxide and benzyne reactants simultaneously.

引用

页码：2537 / 2542

页数：6

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