Large community outbreak of Streptococcus pneumoniae serotype 5 invasive infection in an impoverished, urban population

被引:48
|
作者
Romney, Marc G. [1 ,3 ]
Hull, Mark W. [2 ]
Gustafson, Reka [3 ,4 ]
Sandhu, Jat [4 ]
Champagne, Sylvie [1 ,3 ]
Wong, Titus [3 ]
Nematallah, Anouf [3 ]
Forsting, Sara [4 ]
Daly, Patricia [3 ,4 ]
机构
[1] St Pauls Hosp, Dept Pathol & Lab Med, Providence Hlth Care, Vancouver, BC V6Z 1Y6, Canada
[2] St Pauls Hosp, Dept Med, Providence Hlth Care, Vancouver, BC V6Z 1Y6, Canada
[3] Univ British Columbia, Fac Med, Vancouver, BC, Canada
[4] Vancouver Coastal Hlth, Communicable Dis Control, Vancouver, BC, Canada
关键词
D O I
10.1086/591128
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Background. Streptococcus pneumoniae is a common cause of sporadic invasive infections, but outbreaks of invasive pneumococcal disease are infrequent. In August 2006, a sudden increase in the number of patients presenting with invasive pneumococcal disease was noted at St. Paul's Hospital (Vancouver, Canada). Most patients with severe disease resided in an area referred to as the Downtown Eastside, a neighborhood known for its high rates of poverty and illicit drug use. Methods. Prospective, laboratory-based surveillance for invasive pneumococcal disease was initiated, including on-site serotyping of S. pneumoniae isolates. A vaccination campaign using 23-valent polysaccharide pneumococcal vaccine was launched in the Downtown Eastside. Multiple logistic regression was used to examine the association of sociodemographic variables and medical risk factors with S. pneumoniae serotype status. Results. A single S. pneumoniae serotype (serotype 5) was responsible for 78% of invasive pneumococcal disease cases (137 of 175 cases) during the outbreak period of August 2006-July 2007. The outbreak strain, although fully susceptible to penicillin, caused significant morbidity and placed considerable strain on the acute care system within the Vancouver Coastal Health region. Crack cocaine use was found to be the main independent risk factor associated with invasive pneumococcal disease due to S. pneumoniae serotype 5 (odds ratio, 12.4; 95% confidence interval, 2.22-69.5). Conclusions. A targeted vaccination campaign using polysaccharide pneumococcal vaccine appeared to help control this outbreak. In urban centers with high rates of illicit drug use, vaccination strategies for preventing invasive pneumococcal disease may need to be refined to include individuals who use crack cocaine.
引用
收藏
页码:768 / 774
页数:7
相关论文
共 50 条
  • [41] Hemolytic uremic syndrome associated with invasive Streptococcus pneumoniae infection
    Proulx, F
    Liet, JM
    David, M
    Seidman, E
    Tapiero, B
    Robitaille, P
    Lacroix, J
    PEDIATRICS, 2000, 105 (02) : 462 - 463
  • [42] Invasive Serotype 1 Streptococcus pneumoniae Outbreaks in the South Pacific from 2000 to 2007
    Le Hello, S.
    Watson, M.
    Levy, M.
    Marcon, S.
    Brown, M.
    Yvon, J. F.
    Missotte, I.
    Garin, B.
    JOURNAL OF CLINICAL MICROBIOLOGY, 2010, 48 (08) : 2968 - 2971
  • [43] Clinical and pathological aspects of an outbreak of Streptococcus suis serotype 9 infection in pigs
    Hammerschmitt, Marcia E.
    Schwertz, Claiton I.
    Lopes, Bruna C.
    Pereira, Paula R.
    Frandoloso, Rafael
    Driemeier, David
    PESQUISA VETERINARIA BRASILEIRA, 2022, 42
  • [44] Mathematical Modeling of Streptococcus pneumoniae Colonization, Invasive Infection and Treatment
    Dominguez-Huettinger, Elisa
    Boon, Neville J.
    Clarke, Thomas B.
    Tanaka, Reiko J.
    FRONTIERS IN PHYSIOLOGY, 2017, 8
  • [45] Autoimmune Lymphoproliferative Syndrome Presenting with Invasive Streptococcus pneumoniae Infection
    Oksenhendler, Eric
    Spaan, Andras N.
    Neven, Benedicte
    Stolzenberg, Marie-Claude
    Fusaro, Mathieu
    Casanova, Jean-Laurent
    Rieux-Laucat, Frederic
    Boisson, Bertrand
    Magerus, Aude
    JOURNAL OF CLINICAL IMMUNOLOGY, 2020, 40 (03) : 543 - 546
  • [46] Autoimmune Lymphoproliferative Syndrome Presenting with Invasive Streptococcus pneumoniae Infection
    Eric Oksenhendler
    András N. Spaan
    Bénédicte Neven
    Marie-Claude Stolzenberg
    Mathieu Fusaro
    Jean-Laurent Casanova
    Frédéric Rieux-Laucat
    Bertrand Boisson
    Aude Magérus
    Journal of Clinical Immunology, 2020, 40 : 543 - 546
  • [47] Molecular characterization of Latin American invasive Streptococcus pneumoniae serotype 19A isolates
    Moreno, Jaime
    Duarte, Carolina
    Paula Cassiolato, Ana
    Chanto Chacon, Grettel
    Alarcon, Pedro
    Sanchez, Jacqueline
    Narvaez San Martin, Yolanda
    Valenzuela, Claudia
    Castillo, Wendy
    Garcia Gabarrot, Gabriela
    VACCINE, 2020, 38 (19) : 3524 - 3530
  • [48] Hemolytic uremic syndrome associated with invasive Streptococcus pneumoniae infection
    Cabrera, GR
    Fortenberry, JD
    Butler, JS
    Warshaw, BL
    Cooperstone, BG
    Chambliss, R
    PEDIATRICS, 1997, 100 (03) : 448 - 448
  • [49] Serotype distribution of Streptococcus pneumoniae in children with invasive diseases in Turkey: 2008-2014
    Ceyhan, Mehmet
    Ozsurekci, Yasemin
    Gurler, Nezahat
    Oksuz, Lutfiye
    Aydemir, Sohret
    Ozkan, Sengul
    Yuksekkaya, Serife
    Emiroglu, Melike Keser
    Gultekin, Meral
    Yaman, Akgun
    Kiremitci, Abdurrahman
    Yanik, Keramettin
    Karli, Arzu
    Ozcinar, Hatice
    Aydin, Faruk
    Bayramoglu, Gulcin
    Zer, Yasemin
    Gulay, Zeynep
    Gayyurhan, Efgan Dogan
    Gul, Mustafa
    Ozakin, Cuneyt
    Guducuoglu, Huseyin
    Percin, Duygu
    Akpolat, Nezahat
    Ozturk, Candan
    Camcioglu, Yildiz
    Oncel, Eda Karadag
    Celik, Melda
    Sanal, Laser
    Uslu, Hakan
    HUMAN VACCINES & IMMUNOTHERAPEUTICS, 2016, 12 (02) : 308 - 313
  • [50] SEROTYPE DISTRIBUTION AND ANTIMICROBIAL RESISTANCE OF INVASIVE STREPTOCOCCUS-PNEUMONIAE ISOLATES IN FILIPINO CHILDREN
    CAPEDING, MRZ
    SOMBRERO, LT
    LUCERO, MG
    SANIEL, MC
    JOURNAL OF INFECTIOUS DISEASES, 1994, 169 (02): : 479 - 480