Large community outbreak of Streptococcus pneumoniae serotype 5 invasive infection in an impoverished, urban population

被引:48
|
作者
Romney, Marc G. [1 ,3 ]
Hull, Mark W. [2 ]
Gustafson, Reka [3 ,4 ]
Sandhu, Jat [4 ]
Champagne, Sylvie [1 ,3 ]
Wong, Titus [3 ]
Nematallah, Anouf [3 ]
Forsting, Sara [4 ]
Daly, Patricia [3 ,4 ]
机构
[1] St Pauls Hosp, Dept Pathol & Lab Med, Providence Hlth Care, Vancouver, BC V6Z 1Y6, Canada
[2] St Pauls Hosp, Dept Med, Providence Hlth Care, Vancouver, BC V6Z 1Y6, Canada
[3] Univ British Columbia, Fac Med, Vancouver, BC, Canada
[4] Vancouver Coastal Hlth, Communicable Dis Control, Vancouver, BC, Canada
关键词
D O I
10.1086/591128
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Background. Streptococcus pneumoniae is a common cause of sporadic invasive infections, but outbreaks of invasive pneumococcal disease are infrequent. In August 2006, a sudden increase in the number of patients presenting with invasive pneumococcal disease was noted at St. Paul's Hospital (Vancouver, Canada). Most patients with severe disease resided in an area referred to as the Downtown Eastside, a neighborhood known for its high rates of poverty and illicit drug use. Methods. Prospective, laboratory-based surveillance for invasive pneumococcal disease was initiated, including on-site serotyping of S. pneumoniae isolates. A vaccination campaign using 23-valent polysaccharide pneumococcal vaccine was launched in the Downtown Eastside. Multiple logistic regression was used to examine the association of sociodemographic variables and medical risk factors with S. pneumoniae serotype status. Results. A single S. pneumoniae serotype (serotype 5) was responsible for 78% of invasive pneumococcal disease cases (137 of 175 cases) during the outbreak period of August 2006-July 2007. The outbreak strain, although fully susceptible to penicillin, caused significant morbidity and placed considerable strain on the acute care system within the Vancouver Coastal Health region. Crack cocaine use was found to be the main independent risk factor associated with invasive pneumococcal disease due to S. pneumoniae serotype 5 (odds ratio, 12.4; 95% confidence interval, 2.22-69.5). Conclusions. A targeted vaccination campaign using polysaccharide pneumococcal vaccine appeared to help control this outbreak. In urban centers with high rates of illicit drug use, vaccination strategies for preventing invasive pneumococcal disease may need to be refined to include individuals who use crack cocaine.
引用
收藏
页码:768 / 774
页数:7
相关论文
共 50 条
  • [31] INVASIVE STREPTOCOCCUS PNEUMONIAE SEROTYPE 19A IN THAILAND (2008-2018)
    Chongtrakool, Piriyapom
    Puangprasart, Unchalee
    Phongsamart, Wanatpreeya
    Tribuddharat, Chanwit
    Pummangura, Chalermsri
    Srifuengfung, Somporn
    SOUTHEAST ASIAN JOURNAL OF TROPICAL MEDICINE AND PUBLIC HEALTH, 2022, 53 (01) : 73 - 90
  • [32] An explosive outbreak of Streptococcus pneumoniae serotype-8 infection in a highly vaccinated residential care home, England, summer 2012
    Thomas, H. L.
    Gajraj, R.
    Slack, M. P. E.
    Sheppard, C.
    Hawkey, P.
    Gossain, S.
    Drew, C. M.
    Pebody, R. G.
    EPIDEMIOLOGY AND INFECTION, 2015, 143 (09): : 1957 - 1963
  • [33] Serotype and MLST-based inference of population structure of clinical Streptococcus pneumoniae from invasive and noninvasive pneumococcal disease
    Zhou, Haijian
    Guo, Jiayin
    Qin, Tian
    Ren, Hongyu
    Xu, Yang
    Wang, Chuanqing
    Xu, Xuebin
    INFECTION GENETICS AND EVOLUTION, 2017, 55 : 104 - 111
  • [34] Semisynthetic glycoconjugate vaccine candidate against Streptococcus pneumoniae serotype 5
    Lisboa, Marilda P.
    Khan, Naeem
    Martin, Christopher
    Xu, Fei-Fei
    Reppe, Katrin
    Geissner, Andreas
    Govindan, Subramanian
    Witzenrath, Martin
    Pereira, Claney L.
    Seeberger, Peter H.
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2017, 114 (42) : 11063 - 11068
  • [35] A case of necrotizing fasciitis due to Streptococcus pneumoniae serotype 5 in Saskatchewan
    Dawar, Meenakshi
    Russell, Bob
    McClean, Karen
    Levett, Paul N.
    Tyrrell, Gregory J.
    Irvine, James
    CANADIAN JOURNAL OF INFECTIOUS DISEASES & MEDICAL MICROBIOLOGY, 2008, 19 (01): : 69 - 71
  • [36] Community outbreak of acute respiratory infection by Mycoplasma pneumoniae
    Dominguez, A
    Minguell, S
    Torres, J
    Serrano, A
    Vidal, J
    Salleras, L
    EUROPEAN JOURNAL OF EPIDEMIOLOGY, 1996, 12 (02) : 131 - 134
  • [37] Serotype distribution of invasive, non-invasive and carried Streptococcus pneumoniae in Malaysia: a meta-analysis
    Alex J. J. Lister
    Cheng Foh Le
    Eddy Seong Guan Cheah
    Mohd Nasir Mohd Desa
    David W. Cleary
    Stuart C. Clarke
    Pneumonia, 13
  • [38] Serotype distribution of invasive, non-invasive and carried Streptococcus pneumoniae in Malaysia: a meta-analysis
    Lister, Alex J. J.
    Le, Cheng Foh
    Cheah, Eddy Seong Guan
    Desa, Mohd Nasir Mohd
    Cleary, David W.
    Clarke, Stuart C.
    PNEUMONIA, 2021, 13 (01)
  • [39] Large-scale identificationof serotype 4 Streptococcus pneumoniae virulence factors
    Hava, D
    Camilli, A
    MOLECULAR MICROBIOLOGY, 2002, 45 (05) : 1389 - 1405
  • [40] Hemolytic uremic syndrome associated with invasive Streptococcus pneumoniae infection
    Cabrera, GR
    Fortenberry, JD
    Warshaw, BL
    Chambliss, CR
    Butler, JC
    Cooperstone, BG
    PEDIATRICS, 1998, 101 (04) : 699 - 703