Use of the 13-valent conjugate vaccine has the potential to eliminate pilus carrying isolates as causes of invasive pneumococcal disease

被引：8

作者：

Aguiar, Sandra I. ^{[1
]}

Melo-Cristino, Jose ^{[1
]}

Ramirez, Mario ^{[1
]}

机构：

[1] Univ Lisbon, Fac Med, Inst Med Mol, Inst Microbiol, P-1699 Lisbon, Portugal

来源：

VACCINE | 2012年 / 30卷 / 37期

关键词：

Streptococcus pneumoniae; Conjugate vaccines; Pneumococcal vaccines; Vaccines; Subunit; Fimbriae; Bacterial; STREPTOCOCCUS-PNEUMONIAE; TYPING METHODS; WALLACE COEFFICIENT; IN-VIVO; SEROTYPES; VARIANTS; PORTUGAL; INFECTIONS; VIRULENCE;

D O I：

10.1016/j.vaccine.2012.06.062

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We examined the distribution of the two pilus island loci (PI-1 and PI-2) in all pediatric invasive pneumococcal disease (IPD) isolates recovered in Portugal over the ten year period 1999-2008 (n = 575). While 199 isolates (35%) harbored PI-2, only 98 isolates (17%) harbored PI-1. A decline of isolates carrying PI-1 was observed in the post 7-valent conjugate vaccine (PCV7) period since most PI-1 carrying isolates expressed PCV7 serotypes. On the other hand. the PI-2 increase in the post-PCV7 period was associated mostly with serotypes 1 and 7F. The overall proportion of piliated isolates declined in the period following PCV7 but quickly recovered to pre-PCV7 levels (50%). Only serotypes 19F and 19A contained isolates carrying simultaneously PI-1 and PI-2 and the proportion of isolates carrying both pilus islands remained stable and low. All PI-1 clades were represented in our collection and were associated with multiple serotypes. Over 99% of pilus island carrying isolates belonged to the 13-valent conjugate vaccine serotypes. (c) 2012 Elsevier Ltd. All rights reserved.

引用

页码：5487 / 5490

页数：4

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