Are autoimmune diseases predictable?

被引：55

作者：

Tobon, Gabriel J. ^{[2
,3
,4
]}

Pers, Jacques-Olivier ^{[2
,3
]}

Canas, Carlos A. ^{[4
]}

Rojas-Villarraga, Adriana ^{[1
]}

Youinou, Pierre ^{[2
,3
]}

Anaya, Juan-Manuel ^{[1
]}

机构：

[1] Univ Rosario, Sch Med & Hlth Sci, Ctr Autoimmune Dis Res CREA, Bogota, Colombia

[2] Univ Bretagne Occidentale, EA Immunol & Pathol, Brest, France

[3] CHU Brest, Brest, France

[4] Fdn Valle Lili, Rheumatol Unit, Cali, Colombia

来源：

AUTOIMMUNITY REVIEWS | 2012年 / 11卷 / 04期

关键词：

Autoimmune diseases; Prediction; Positive predictive value; Auto-antibodies; Genetic susceptibility; SYSTEMIC-LUPUS-ERYTHEMATOSUS; HLA-CLASS-II; LATIN-AMERICAN PATIENTS; RHEUMATOID-ARTHRITIS; AUTOANTIBODY POSITIVITY; DNA METHYLATION; T-CELLS; ANTIBODIES; RISK; ONSET;

D O I：

10.1016/j.autrev.2011.10.004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Autoimmune diseases are complex diseases resulting of the interaction between both genetics and environmental factors over time. Different phases in the development of autoimmune diseases are characterized by the detection of serum autoantibodies several months or years before the onset of clinical manifestations and subsequent diagnosis. In addition to serum antibodies, genetic susceptibility factors may predict the future development of the disease. Currently, prediction in type 1 diabetes is the most accurate, with the analysis of genetic susceptibility factors in first-degree relatives of patients and several autoantibody tests. In the future, multiple antibodies test, in combination with the analysis of genetics, epigenetics and immunological anomalies in fine models may allow the precise prediction in autoimmune diseases. Prevention measures might thus be introduced as an attempt to avoid or delay the disease. (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：259 / 266

页数：8

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