Developmental Delays in Children With Neurofibromatosis Type 1

被引：28

作者：

Soucy, Elizabeth A. ^{[1
]}

Gao, Feng ^{[2
]}

Gutmann, David H. ^{[1
]}

Dunn, Courtney M. ^{[1
]}

机构：

[1] Washington Univ, Sch Med, Dept Neurol, St Louis, MO 63110 USA

[2] Washington Univ, Sch Med, Dept Biostat, St Louis, MO 63110 USA

来源：

JOURNAL OF CHILD NEUROLOGY | 2012年 / 27卷 / 05期

关键词：

gross motor; fine motor; neurofibromatosis type 1; NF1; inherited cancer syndrome; brain tumor; COGNITIVE FUNCTION; MOTOR; ADOLESCENTS; ADHD;

D O I：

10.1177/0883073811423974

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

It is well documented that children with neurofibromatosis type 1 are at high risk for a variety of cognitive and learning deficits. The current study investigated the use of a developmental screening tool, the Parents' Evaluation of Developmental Status: Developmental Milestones, as an accurate, reliable, and efficient indicator of developmental delays. Sixty-eight percent of children with neurofibromatosis type 1 were found to have a developmental delay in at least 1 of the 8 areas tested by the Parents' Evaluation of Developmental Status: Developmental Milestones. Significant developmental abnormalities were found in the areas of fine motor (35%), gross motor (52%), and math/premath (31%). A positive association was found between the presence of a previously diagnosed optic glioma and math/premath delays (chi(2) = 0.0022) and between male sex and fine motor delays (chi(2) = 0.0325). The Parents' Evaluation of Developmental Status: Developmental Milestones assessment demonstrates the high presence of developmental delays in children with neurofibromatosis type 1 and the need for aggressive and early screening.

引用

页码：641 / 644

页数：4

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