Axl of Evil?

被引：5

作者：

Aplin, Andrew E. ^{[1
,2
,3
]}

机构：

[1] Thomas Jefferson Univ, Dept Canc Biol, Philadelphia, PA 19107 USA

[2] Thomas Jefferson Univ, Kimmel Canc Ctr, Philadelphia, PA 19107 USA

[3] Thomas Jefferson Univ, Dept Dermatol & Cutaneous Biol, Philadelphia, PA 19107 USA

来源：

JOURNAL OF INVESTIGATIVE DERMATOLOGY | 2011年 / 131卷 / 12期

关键词：

TRANSCRIPTION FACTOR; MELANOMA-CELLS; KINASE; RESISTANCE; SURVIVAL; LEUKEMIA;

D O I：

10.1038/jid.2011.308

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Receptor tyrosine kinases (RTKs) play key roles in the initiation and progression of human skin cancers, yet the importance of some RTKs remains poorly understood. In this issue, Sensi et al. provide new insights into the expression and function of the RTK, Axl, in melanoma. The investigators show that Axl is frequently expressed in melanoma cell lines, particularly mutant NRAS-harboring lines, and that Axl activation by its ligand, Gas6, probably occurs via both autocrine and paracrine mechanisms. Gene signatures from Axl-expressing cell lines are similar to published signatures from poorly differentiated tumors displaying high metastatic potential. Functionally, Axl was required for the invasive and migratory properties of Axl-expressing melanoma cell lines. These data emphasize that targeting the Gas6-Axl signaling axis should be investigated as a strategy to inhibit prometastatic properties in poorly differentiated melanomas.

引用

页码：2343 / 2345

页数：3

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