Cross-sectional study on acrylamide hemoglobin adducts in subpopulations from the European Prospective Investigation into Cancer and Nutrition (EPIC) study

被引：62

作者：

Vesper, Hubert W. ^{[1
]}

Slimani, Nadia ^{[2
]}

Hallmans, Goran ^{[3
]}

Tjonneland, Anne ^{[4
]}

Agudo, Antonio ^{[5
]}

Benetou, Vassiliki ^{[6
]}

Bingham, Sheila ^{[7
]}

Boeing, Heiner ^{[8
]}

Boutron-Ruault, Marie-Christine ^{[9
]}

Bueno-de-Mesquita, H. Bas ^{[10
]}

Chirlaque, Dolores ^{[11
]}

Clavel-Chapelon, Francoise ^{[9
]}

Crowe, Francesca ^{[12
]}

Drogan, Dagmar ^{[8
]}

Ferrari, Pietro ^{[2
]}

Johansson, Ingegerd ^{[3
]}

Kaaks, Rudolf ^{[13
]}

Linseisen, Jakob ^{[13
]}

Lund, Eiliv ^{[14
]}

Manjer, Jonas ^{[15
]}

Mattiello, Amalia ^{[16
]}

Palli, Domenico ^{[17
]}

Peeters, Petra H. M. ^{[18
]}

Rinaldi, Sabina ^{[2
]}

Skeie, Guri ^{[14
]}

Trichopoulou, Antonia ^{[6
]}

Vineis, Paolo ^{[19
]}

Wirfalt, Elisabet ^{[20
]}

Overvad, Kim ^{[21
]}

Stromberg, Ulf ^{[20
]}

机构：

[1] Ctr Dis Control & Prevent, Atlanta, GA 30341 USA

[2] Int Agcy Res Canc, F-69372 Lyon, France

[3] Umea Univ, Dept Publ Hlth & Clin Med, Umea, Sweden

[4] Danish Canc Soc, Copenhagen, Denmark

[5] Catalan Inst Oncol, Lhospitalet De Llobregat, Spain

[6] Univ Athens, Sch Med, GR-11527 Athens, Greece

[7] Ctr Nutr Epidemiol Canc Prevent & Survival, Cambridge, England

[8] German Inst Human Nutr, Berlin, Germany

[9] Inst Gustave Roussy, INSERM ER120, Villejuif, France

[10] Natl Inst Publ Hlth & Environm, NL-3720 BA Bilthoven, Netherlands

[11] Murcia Hlth Council, Murcia, Spain

[12] Univ Oxford, Oxford, England

[13] German Canc Res Ctr, D-6900 Heidelberg, Germany

[14] Univ Tromso, Tromso, Norway

[15] Malmo Univ Hosp, Malmo, Sweden

[16] Univ Naples Federico 2, Naples, Italy

[17] CSPO Sci Inst Tuscany, Florence, Italy

[18] Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands

[19] Univ London Imperial Coll Sci Technol & Med, London, England

[20] Lund Univ, Lund, Sweden

[21] Aarhus Univ Hosp, Aalborg, Denmark

来源：

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | 2008年 / 56卷 / 15期

关键词：

acrylamide; glycidamide; European Prospective Investigation into Cancer; smoking; alcohol consumption; gender;

D O I：

10.1021/jf703750t

中图分类号：

S [农业科学];

学科分类号：

09 ;

摘要：

Acrylamide exposure was investigated in subgroups of the EPIC study population (510 subjects from 9 European countries, randomly selected and stratified by age, gender, and smoking status) using hemoglobin adducts of acrylamide (HbAA) and its primary metabolite glycidamide (HbGA). Blood samples were analyzed for HbAA and HbGA by HPLC/MS/MS. Statistical models for HbAA and HbGA were developed including body mass index (BMI), educational level, and physical activity. A large variability in acrylamide exposure and metabolism between individuals and country groups was observed with HbAA and HbGA values ranging between 15-623 and 8-377 pmol/g of Hb, respectively. Both adducts differed significantly by country, sex, and smoking status. HbGA values were significantly lower in high alcohol consumers than in moderate consumers. With increasing BMI, HbGA in nonsmokers and HbAA in smokers decreased significantly. In the assessment of potential health effects related to acrylamide exposure, country of origin, BMI, alcohol consumption, sex, and smoking status should be considered.

引用

页码：6046 / 6053

页数：8

共 35 条

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