Recurrence of Chronic Active Epstein-Barr Virus Infection from Donor Cells after Achieving Complete Response Through Allogeneic Bone Marrow Transplantation

被引：13

作者：

Arai, Ayako ^{[1
]}

Imadome, Ken-Ichi ^{[2
]}

Wang, Ludan ^{[1
]}

Wu, Nan ^{[1
]}

Kurosu, Tetsuya ^{[1
]}

Wake, Atsushi ^{[4
]}

Yamamoto, Hisashi ^{[4
]}

Ota, Yasunori ^{[3
]}

Harigai, Masayoshi ^{[5
]}

Fujiwara, Shigeyoshi ^{[2
]}

Miura, Osamu ^{[1
]}

机构：

[1] Tokyo Med & Dent Univ, Grad Sch Med & Dent Sci, Dept Hematol, Tokyo, Japan

[2] Natl Res Inst Child Hlth & Dev, Dept Infect Dis, Tokyo, Japan

[3] Toranomon Gen Hosp, Dept Pathol, Tokyo, Japan

[4] Toranomon Gen Hosp, Dept Hematol, Tokyo, Japan

[5] Tokyo Med & Dent Univ, Dept Pharmacovigilance, Grad Sch Med & Dent Sci, Tokyo, Japan

来源：

INTERNAL MEDICINE | 2012年 / 51卷 / 07期

关键词：

chronic active Epstein-Barr virus infection; bone marrow transplantation; systemic lupus erythematosus; LYMPHOPROLIFERATIVE-DISORDER; EBV INFECTION; T-CELLS; PERFORIN;

D O I：

10.2169/internalmedicine.51.6769

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We report the case of a 35-year-old woman with chronic active Epstein-Barr virus (EBV) infection (CAEBV). She underwent allogeneic bone marrow transplantation (BMT) from an unrelated male donor and achieved a complete response. However, her CAEBV relapsed one year after BMT. EBV-infected cells proliferated clonally and revealed a 46XY karyotype. In addition, the infecting EBV strain differed from that detected before BMT. These findings indicated that her disease had developed from donor cells. This is the first report of donor cell-derived CAEBV that recurred after transplantation, suggesting that host factors may be responsible for the development of this disease.

引用

页码：777 / 782

页数：6

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