Usefulness of Serial N-terminal Pro-B-type Natriuretic Peptide Measurements to Predict Cardiac Death in Acute and Chronic Dilated Cardiomyopathy in Children

被引:23
作者
den Boer, Susanna L. [1 ]
Rizopoulos, Dimitris [2 ]
Sarvaas, Gideon J. du Marchie [3 ]
Backx, Ad P. C. M. [4 ]
ten Harkel, Arend D. J. [5 ]
van Iperen, Gabrielle G. [6 ]
Rammeloo, Lukas A. J. [7 ]
Tanke, Ronald B. [8 ]
Boersma, Eric [9 ]
Helbing, Willem A. [1 ]
Dalinghaus, Michiel [1 ]
机构
[1] Erasmus Univ, Med Ctr, Sophia Childrens Hosp, Div Pediat Cardiol, Rotterdam, Netherlands
[2] Erasmus Univ, Med Ctr, Dept Biostat, Rotterdam, Netherlands
[3] Univ Groningen, Univ Med Ctr Groningen, Div Pediat Cardiol, Beatrix Childrens Hosp, Groningen, Netherlands
[4] Emma Childrens Hosp, Acad Med Ctr, Div Pediat Cardiol, Amsterdam, Netherlands
[5] Leiden Univ, Med Ctr, Dept Pediat, Div Pediat Cardiol, Leiden, Netherlands
[6] Univ Med Ctr Utrecht, Wilhelmina Childrens Hosp, Div Pediat Cardiol, Utrecht, Netherlands
[7] Free Univ Amsterdam, Med Ctr, Dept Pediat, Div Pediat Cardiol, Amsterdam, Netherlands
[8] Radboud Univ Nijmegen, Med Ctr, Dept Pediat, Div Pediat Cardiol, Nijmegen, Netherlands
[9] Erasmus Univ, Med Ctr, Dept Cardiol, Rotterdam, Netherlands
关键词
CHRONIC HEART-FAILURE; VAL-HEFT; CARDIOVASCULAR EVENTS; SERUM CREATININE; TRIAL; BNP; TRANSPLANTATION; DYSFUNCTION; CARVEDILOL; MANAGEMENT;
D O I
10.1016/j.amjcard.2016.08.053
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
N-terminal pro-B-type natriuretic peptide (NT-proBNP) is an important predictor of outcome in adults with heart failure. In children with heart failure secondary to dilated cardiomyopathy (DC) markers that reliably predict disease progression and outcome during follow-up are scarce. We investigated whether serial NT-proBNP measurements were predictive for outcome in children with DC. All available NT-proBNP measurements in children with DC were analyzed. Linear mixed-effect models and Cox regression were used to analyze the predictive value of NT-proBNP on the end point of cardiac death (death, heart transplantation, or mechanical circulatory support). During 7 years, 115 patients were included. At diagnosis, median NT-proBNP was high and not predictive for outcome. At any time during follow-up, a twofold higher NT-proBNP resulted in a 2.9 times higher risk in the first year (p <0.001) and a 1.8 times higher risk thereafter (p <0.001). Furthermore, at any time, the slope of log10(NT-proBNP) was significantly predictive for the risk of an end point (0 to 30 days hazard ratio [HR] 3.5, >30 days HR 2.9; >1 year HR 6.4). In patients with idiopathic DC (IDC) at 30 days after diagnosis, NT-proBNP >= 7,990 pg/ml showed a 1- and 2-year eyent-free survival of 79% and 71% and >1 year after diagnosis NT-proBNP >= 924 pg/ml showed a 2- and 5-year event-free survival of 50% and 40%, whereas below both thresholds event-free survival was 100%. In non-IDC, these thresholds were not predictive for outcome. In conclusion, NT-proBNP at any time during follow-up and its change over time were significantly predictive for the risk of cardiac death in children with DC. In children with IDC >1 year after diagnosis, NTproBNP >924 pg/ml identified a subgroup with a poor outcome. (C) 2016 Published by Elsevier Inc.
引用
收藏
页码:1723 / 1729
页数:7
相关论文
共 34 条
[11]   N-terminal pro-brain natriuretic peptide -: A new gold standard in predicting mortality in patients with advanced heart failure [J].
Gardner, RS ;
Özalp, F ;
Murday, AJ ;
Robb, SD ;
McDonagh, TA .
EUROPEAN HEART JOURNAL, 2003, 24 (19) :1735-1743
[12]   NT-ProBNP: The mechanism behind the marker [J].
Hall, C .
JOURNAL OF CARDIAC FAILURE, 2005, 11 (05) :S81-S83
[13]   Plasma brain natriuretic peptide-guided therapy to improve outcome in heart failure -: The STARS-BNP multicenter study [J].
Jourdain, Patrick ;
Jondeau, Guillaume ;
Funck, Francois ;
Gueffet, Pascal ;
Le Helloco, Alain ;
Donal, Erwan ;
Aupetit, Jean F. ;
Aumont, Marie C. ;
Galinier, Michel ;
Eicher, Jean C. ;
Cohen-Solal, Alain ;
Juilliere, Yves .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2007, 49 (16) :1733-1739
[14]   Clinical practice - Heart failure in children. Part II: current maintenance therapy and new therapeutic approaches [J].
Kantor, Paul F. ;
Mertens, Luc L. .
EUROPEAN JOURNAL OF PEDIATRICS, 2010, 169 (04) :403-410
[15]   Clinical Implications of Serial Serum N-Terminal Prohormone Brain Natriuretic Peptide Levels in the Prediction of Outcome in Children With Dilated Cardiomyopathy [J].
Kim, Geena ;
Lee, Ok Jeong ;
Kang, I-Seok ;
Song, Jinyoung ;
Huh, June .
AMERICAN JOURNAL OF CARDIOLOGY, 2013, 112 (09) :1455-1460
[16]   A more accurate method to estimate glomerular filtration rate from serum creatinine: A new prediction equation [J].
Levey, AS ;
Bosch, JP ;
Lewis, JB ;
Greene, T ;
Rogers, N ;
Roth, D .
ANNALS OF INTERNAL MEDICINE, 1999, 130 (06) :461-+
[17]   Primary Results of the HABIT Trial (Heart Failure Assessment With BNP in the Home) [J].
Maisel, Alan ;
Barnard, Denise ;
Jaski, Brian ;
Frivold, Geir ;
Marais, John ;
Azer, Maged ;
Miyamoto, Michael I. ;
Lombardo, Dawn ;
Kelsay, Damon ;
Borden, Kelly ;
Iqbal, Navaid ;
Taub, Pam R. ;
Kupfer, Ken ;
Clopton, Paul ;
Greenberg, Barry .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2013, 61 (16) :1726-1735
[18]   The clinical utility of brain natriuretic peptide in paediatric left ventricular failure [J].
Mangat, Jasveer ;
Carter, Catherine ;
Riley, Gillian ;
Foo, Ying ;
Burch, Michael .
EUROPEAN JOURNAL OF HEART FAILURE, 2009, 11 (01) :48-52
[19]   Prognostic value of changes in N-terminal pro-brain natriuretic peptide in Val-HeFT (Valsartan Heart Failure Trial) [J].
Masson, Serge ;
Latini, Roberto ;
Anand, Inder S. ;
Barlera, Simona ;
Angelici, Laura ;
Vago, Tarcisio ;
Tognoni, Gianni ;
Cohn, Jay N. .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2008, 52 (12) :997-1003
[20]   Direct comparison of B-Type natriuretic peptide (BNP) and amino-terminal proBNP in a large population of patients with chronic and symptomatic heart failure: The valsartan heart failure (Val-HeFT) data [J].
Masson, Serge ;
Latini, Roberto ;
Anand, Inder S. ;
Vago, Tarcisio ;
Angelici, Laura ;
Barlera, Simona ;
Missov, Emil D. ;
Clerico, Aldo ;
Tognoni, Gianni ;
Cohn, Jay N. .
CLINICAL CHEMISTRY, 2006, 52 (08) :1528-1538