Meningeal lymphatics clear erythrocytes that arise from subarachnoid hemorrhage

被引：155

作者：

Chen, Jinman ^{[1
,2
,3
,4
]}

Wang, Linmei ^{[5
]}

Xu, Hao ^{[1
,2
,4
]}

Xing, Lianping ^{[6
,7
]}

Zhuang, Zixin ^{[1
,2
,3
,4
]}

Zheng, Yangkang ^{[1
,2
,4
]}

Li, Xuefei ^{[1
,2
,4
]}

Wang, Chinyun ^{[1
,2
,8
]}

Chen, Shaohua ^{[1
,2
,4
]}

Guo, Zibin ^{[9
]}

Liang, Qianqian ^{[1
,2
,4
]}

Wang, Yongjun ^{[1
,2
,3
,4
]}

机构：

[1] Shanghai Univ Tradit Chinese Med, Longhua Hosp, 725 Wan Ping South Rd, Shanghai 200032, Peoples R China

[2] Shanghai Univ Tradit Chinese Med, Spine Inst, 725 Wan Ping South Rd, Shanghai 200032, Peoples R China

[3] Shanghai Univ Tradit Chinese Med, Sch Rehabil Sci, 1200 Cailun Rd, Shanghai 201203, Peoples R China

[4] Shanghai Univ Tradit Chinese Med, Minist Educ, Key Lab Theory & Therapy Muscles & Bones, 1200 Cailun Rd, Shanghai 201203, Peoples R China

[5] Shanghai Univ Tradit Chinese Med, Sch Basic Med, Dept Anat, 1200 Cailun Rd, Shanghai 201203, Peoples R China

[6] Univ Rochester, Med Ctr, Dept Pathol & Lab Med, 601 Elmwood Ave, Rochester, NY 14642 USA

[7] Univ Rochester, Med Ctr, Ctr Musculoskeletal Res, 601 Elmwood Ave, Rochester, NY 14642 USA

[8] Nanjing Univ Chinese Med, Int Educ Coll, 138 Xianlin Rd, Nanjing 210029, Peoples R China

[9] Guangzhou Univ Tradit Chinese Med, Clin Med Coll 4, 232 Huandong Rd, Guangzhou 510006, Guangdong, Peoples R China

来源：

NATURE COMMUNICATIONS | 2020年 / 11卷 / 01期

基金：

国家重点研发计划;

关键词：

CEREBROSPINAL-FLUID; BRAIN-INJURY; INTESTINAL INFLAMMATION; MOUSE MODEL; SYSTEM; LYMPHANGIOGENESIS; MICROGLIA; VASOSPASM; DRAINAGE; ASSOCIATION;

D O I：

10.1038/s41467-020-16851-z

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Extravasated erythrocytes in cerebrospinal fluid (CSF) critically contribute to the pathogenesis of subarachnoid hemorrhage (SAH). Meningeal lymphatics have been reported to drain macromolecules and immune cells from CSF into cervical lymph nodes (CLNs). However, whether meningeal lymphatics are involved in clearing extravasated erythrocytes in CSF after SAH remains unclear. Here we show that a markedly higher number of erythrocytes are accumulated in the lymphatics of CLNs and meningeal lymphatics after SAH. When the meningeal lymphatics are depleted in a mouse model of SAH, the degree of erythrocyte aggregation in CLNs is significantly lower, while the associated neuroinflammation and the neurologic deficits are dramatically exacerbated. In addition, during SAH lymph flow is increased but without significant lymphangiogenesis and lymphangiectasia. Taken together, this work demonstrates that the meningeal lymphatics drain extravasated erythrocytes from CSF into CLNs after SAH, while suggesting that modulating this draining may offer therapeutic approaches to alleviate SAH severity. Extravasated erythrocytes in cerebrospinal fluid (CSF) contribute to the pathogenesis of subarachnoid haemorrhage (SAH). Here, the authors show that meningeal lymphatics drain extravasated erythorcytes and that blockage of this drainage aggravates SAH severity.

引用

页数：15

共 58 条

[1] Hemoglobin and heme scavenging [J].