Under the internal dissipative condition, the Cauchy problem for inhomogeneous quasilinear hyperbolic systems with small initial data admits a unique global C-1 solution, which exponentially decays to zero as t -> +infinity, while if the coefficient matrix Theta of boundary conditions satisfies the boundary dissipative condition, the mixed initialboundary value problem with small initial data for quasilinear hyperbolic systems with nonlinear terms of at least second order admits a unique global C-1 solution, which also exponentially decays to zero as t -> +infinity. In this paper, under more general conditions, the authors investigate the combined effect of the internal dissipative condition and the boundary dissipative condition, and prove the global existence and exponential decay of the C-1 solution to the mixed initial-boundary value problem for quasilinear hyperbolic systems with small initial data. This stability result is applied to a kind of models, and an example is given to show the possible exponential instability if the corresponding conditions are not satisfied.