Synthesis and Vacuum Cold Spray Deposition of Biofunctionalized Nanodiamond/Hydroxyapatite Nanocomposite for Biomedical Applications

被引：8

作者：

Li, Deyan ^{[1
,2
]}

Chen, Xiuyong ^{[1
]}

Gong, Yongfeng ^{[1
]}

Zhang, Botao ^{[3
]}

Liu, Yi ^{[1
]}

Jin, Peipeng ^{[2
]}

Li, Hua ^{[1
]}

机构：

[1] Chinese Acad Sci, Key Lab Marine Mat & Related Technol, Key Lab Marine Mat & Protect Technol Zhejiang Pro, Ningbo Inst Mat Technol & Engn, Ningbo 315201, Zhejiang, Peoples R China

[2] Qinghai Univ, Sch Mech Engn, Xining 810016, Qinghai, Peoples R China

[3] Chinese Acad Sci, Cixi Inst Biomed Engn, Ningbo Inst Mat Technol & Engn, Ningbo 315201, Zhejiang, Peoples R China

来源：

ADVANCED ENGINEERING MATERIALS | 2017年 / 19卷 / 12期

基金：

中国博士后科学基金; 中国国家自然科学基金;

关键词：

biofunctionalized nanodiamond/hydroxyapatite nanocomposite; biomedical coating; bone morphogenetic proteins 2; cell behavior; vacuum cold spray; BONE MORPHOGENETIC PROTEIN-2; DRUG-DELIVERY; NANODIAMOND; COATINGS; COMPOSITE; BIOCOMPATIBILITY; DIFFERENTIATION; MICROSTRUCTURE; NANOTECHNOLOGY;

D O I：

10.1002/adem.201700363

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Insufficient biological performances of titanium alloys have been the long-standing problems for their clinical applications. Here, we report synthesis of novel hydroxyapatite/nanodiamond-bone morphogenetic protein 2 (HA-ND/BMP2) composite powder and their coatings deposited by vacuum cold spray operated at room temperature. The microstructure and chemistry of the HA-ND/BMP2 powder and coatings are characterized by transmission electron microscopy, field-emission scanning electron microscopy, thin-film X-ray diffraction, Raman spectrometry, and X-ray photoelectron spectroscopy. In vitro growth assay of osteoblasts on the coatings showed that the biofunctionalized nanodiamonds promoted cell adhesion and proliferation. This study provides a promising technical route for constructing biofunctionalized nanocomposites coatings for potential biomedical applications.

引用

页数：6

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