Synthesis and Vacuum Cold Spray Deposition of Biofunctionalized Nanodiamond/Hydroxyapatite Nanocomposite for Biomedical Applications

被引：8
|
作者：
Li, Deyan [1 ,2 ]
Chen, Xiuyong [1 ]
Gong, Yongfeng [1 ]
Zhang, Botao [3 ]
Liu, Yi [1 ]
Jin, Peipeng [2 ]
Li, Hua [1 ]
机构：
[1] Chinese Acad Sci, Key Lab Marine Mat & Related Technol, Key Lab Marine Mat & Protect Technol Zhejiang Pro, Ningbo Inst Mat Technol & Engn, Ningbo 315201, Zhejiang, Peoples R China
[2] Qinghai Univ, Sch Mech Engn, Xining 810016, Qinghai, Peoples R China
[3] Chinese Acad Sci, Cixi Inst Biomed Engn, Ningbo Inst Mat Technol & Engn, Ningbo 315201, Zhejiang, Peoples R China
来源：
ADVANCED ENGINEERING MATERIALS | 2017年 / 19卷 / 12期
基金：
中国博士后科学基金; 中国国家自然科学基金;
关键词：
biofunctionalized nanodiamond/hydroxyapatite nanocomposite; biomedical coating; bone morphogenetic proteins 2; cell behavior; vacuum cold spray; BONE MORPHOGENETIC PROTEIN-2; DRUG-DELIVERY; NANODIAMOND; COATINGS; COMPOSITE; BIOCOMPATIBILITY; DIFFERENTIATION; MICROSTRUCTURE; NANOTECHNOLOGY;
D O I：
10.1002/adem.201700363
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
Insufficient biological performances of titanium alloys have been the long-standing problems for their clinical applications. Here, we report synthesis of novel hydroxyapatite/nanodiamond-bone morphogenetic protein 2 (HA-ND/BMP2) composite powder and their coatings deposited by vacuum cold spray operated at room temperature. The microstructure and chemistry of the HA-ND/BMP2 powder and coatings are characterized by transmission electron microscopy, field-emission scanning electron microscopy, thin-film X-ray diffraction, Raman spectrometry, and X-ray photoelectron spectroscopy. In vitro growth assay of osteoblasts on the coatings showed that the biofunctionalized nanodiamonds promoted cell adhesion and proliferation. This study provides a promising technical route for constructing biofunctionalized nanocomposites coatings for potential biomedical applications.
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页数：6
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