Neuromedin B receptor antagonist suppresses tumor angiogenesis and tumor growth in vitro and in vivo

被引：24
作者：
Park, Hyun-Joo
Kim, Su-Ryun
Kim, Mi-Kyoung
Choi, Kyu-Sil [2 ]
Jang, Hye-Ock
Yun, Il
Bae, Soo-Kyung
Bae, Moon-Kyoung [1 ]
机构：
[1] Pusan Natl Univ, Sch Dent, Dept Oral Physiol, Yangsan 626870, South Korea
[2] Sungkyunkwan Univ, Mol & Cellular Imaging Ctr, Samsung Biomed Res Inst, Sch Med, Seoul 136710, South Korea
来源：
CANCER LETTERS | 2011年 / 312卷 / 01期
关键词：
Neuromedin B receptor antagonist; Vascular endothelial cells; Angiogenesis; Breast cancer cells; Tumor growth; GASTRIN-RELEASING-PEPTIDE; BOMBESIN-LIKE PEPTIDES; ACTIVATED PROTEIN-KINASE; CANCER CELL-LINES; HUMAN BREAST; SIGNAL-TRANSDUCTION; EPITHELIAL-CELLS; GENE-EXPRESSION; DISEASE STATES; PROLIFERATION;
D O I：
10.1016/j.canlet.2011.08.014
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Neuromedin B (NMB), a member of the mammalian bombesin-like peptide family, and its receptor were aberrantly expressed in vascularized solid tumors. Here, the NMB receptor (NMB-R) antagonist PD168368 specifically inhibited both NMB-induced in vivo and in vitro angiogenesis. In addition, PD168368 showed growth inhibitory effects on MDA-MB-231 breast cancer cells by inducing cell cycle arrest and apoptosis. Furthermore, PD168368 effectively suppressed tumor growth in a xenograft model of breast tumor in vivo. Overall, NMB-R antagonist exhibited a significant antitumor activity by simultaneously inhibiting neovascularization and cancer cell growth, thereby suggesting that NMB-R could be a potential therapeutic target for cancer treatment. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：117 / 127
页数：11
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