Neuromedin B receptor antagonist suppresses tumor angiogenesis and tumor growth in vitro and in vivo

被引：23

作者：

Park, Hyun-Joo

Kim, Su-Ryun

Kim, Mi-Kyoung

Choi, Kyu-Sil ^{[2
]}

Jang, Hye-Ock

Yun, Il

Bae, Soo-Kyung

Bae, Moon-Kyoung ^{[1
]}

机构：

[1] Pusan Natl Univ, Sch Dent, Dept Oral Physiol, Yangsan 626870, South Korea

[2] Sungkyunkwan Univ, Mol & Cellular Imaging Ctr, Samsung Biomed Res Inst, Sch Med, Seoul 136710, South Korea

来源：

CANCER LETTERS | 2011年 / 312卷 / 01期

关键词：

Neuromedin B receptor antagonist; Vascular endothelial cells; Angiogenesis; Breast cancer cells; Tumor growth; GASTRIN-RELEASING-PEPTIDE; BOMBESIN-LIKE PEPTIDES; ACTIVATED PROTEIN-KINASE; CANCER CELL-LINES; HUMAN BREAST; SIGNAL-TRANSDUCTION; EPITHELIAL-CELLS; GENE-EXPRESSION; DISEASE STATES; PROLIFERATION;

D O I：

10.1016/j.canlet.2011.08.014

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Neuromedin B (NMB), a member of the mammalian bombesin-like peptide family, and its receptor were aberrantly expressed in vascularized solid tumors. Here, the NMB receptor (NMB-R) antagonist PD168368 specifically inhibited both NMB-induced in vivo and in vitro angiogenesis. In addition, PD168368 showed growth inhibitory effects on MDA-MB-231 breast cancer cells by inducing cell cycle arrest and apoptosis. Furthermore, PD168368 effectively suppressed tumor growth in a xenograft model of breast tumor in vivo. Overall, NMB-R antagonist exhibited a significant antitumor activity by simultaneously inhibiting neovascularization and cancer cell growth, thereby suggesting that NMB-R could be a potential therapeutic target for cancer treatment. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

引用

页码：117 / 127

页数：11

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