Self-assembly of a DNA dodecahedron from 20 trisoligonucleotides with C3h linkers

被引：129
|
作者：
Zimmermann, Jan [1 ]
Cebulla, Martin R. J. [1 ]
Moenninghoff, Sven [1 ]
von Kiedrowski, Guenter [1 ]
机构：
[1] Ruhr Univ Bochum, Lehrstuhl Organ Chem 1, D-44780 Bochum, Germany
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 19期
关键词：
DNA structures; nanostructures; self-assembly; supramolecular chemistry; trisoligonucleotides;
D O I：
10.1002/anie.200702682
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
(Figure Presented). Can 20 trisoligonucleotides with 20 x 3 individual sequences be programmed to self-assemble into a DNA dodecahedron? The answer is yes if one starts from a new generation of trisoligonucleotides based on C 3h-symmetric linkers with proper flexibility. The resulting dodecahedron has C1 symmetry and may facilitate the construction of multimodular scaffolds in the future. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：3626 / 3630
页数：5
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