Successful Treatment of Relapsed Pediatric Acute Myeloid Leukemia Presenting as Central Nervous System Myeloid Sarcoma: A Single-Institution Case Series

被引：3

作者：

Bujold, Kenneth E. ^{[1
]}

Dandekar, Smita ^{[2
]}

Barbour, Mustafa ^{[3
]}

机构：

[1] Baystate Childrens Hosp, Dept Pediat Hematol Oncol, Springfield, MA USA

[2] Penn State Milton S Hershey Med Ctr, Dept Pediat Hematol Oncol, Hershey, PA USA

[3] Univ Louisville, Dept Pediat Hematol Oncol, Louisville, KY 40292 USA

来源：

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY | 2020年 / 42卷 / 04期

关键词：

pediatric; acute myeloid leukemia; relapse; myeloid sarcoma; treatment; CEREBELLAR GRANULOCYTIC SARCOMA; CEREBROSPINAL-FLUID; CHILDHOOD; CHILDREN; CLOFARABINE; TOPOTECAN; THIOTEPA; TRIAL;

D O I：

10.1097/MPH.0000000000001383

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Relapsed acute myeloid leukemia presenting as an isolated central nervous system myeloid sarcoma (CNS MS) is very rare and generally entails poor outcomes. CNS MS treatment is not well defined and can include systemic chemotherapy, intrathecal chemotherapy, radiation therapy, or hematopoietic stem cell transplant. Thiotepa, vinorelbine, topotecan, and clofarabine (TVTC) has been successful for reinduction therapy in relapsed/refractory leukemia to induce remission before hematopoietic stem cell transplant. There is no published evidence of TVTC being utilized for CNS MS. In this series, we report 2 symptomatic patients with isolated CNS MS at relapse who demonstrated near complete resolution after reinduction with TVTC and additional intrathecal chemotherapy.

引用

页码：319 / 321

页数：3

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