Enantiomer resolution screening strategy using multiple immobilised polysaccharide-based chiral stationary phases

被引：109

作者：

Zhang, Tong ^{[1
]}

Nguyen, Dung ^{[1
]}

Franco, Pilar ^{[1
]}

机构：

[1] Chiral Tecnol Europe, F-67404 Illkirch Graffenstaden, France

来源：

JOURNAL OF CHROMATOGRAPHY A | 2008年 / 1191卷 / 1-2期

关键词：

chemically immobilised polysaccharide-based chiral stationary phases; enantiomer resolution by liquid chromatography; complementary properties; method development;

D O I：

10.1016/j.chroma.2007.12.026

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

CHIRALPAK IA, CHIRALPAK IB and CHIRALPAK IC are a new generation of chiral packing materials for resolution of enantiomers by chromatography. They are all prepared by chemical immobilisation of the respective polysaccharide derivatives onto a supporting silica matrix. The present article aims to establish an understanding of the global enantioselective profiles of this series of chiral stationary phases (CSPs). When used in combination, high success rates for enantiomer resolution could be achieved. These three CSPs exhibit an exceptional level of complementary chiral recognition characteristics by applying common screening and method optimisation strategies. (c) 2007 Elsevier B.V. All rights reserved.

引用

页码：214 / 222

页数：9