Nanomaterials Respond to Lysosomal Function for Tumor Treatment

被引:11
作者
Tian, Xuexia [1 ]
Shi, Anhua [1 ]
Yin, Hang [1 ]
Wang, Yutian [1 ]
Liu, Qiaoyan [1 ]
Chen, Wenling [2 ]
Wu, Junzi [1 ]
机构
[1] Yunnan Univ Chinese Med, Dept Basic Med, Kunming 650500, Peoples R China
[2] Yunnan Univ Chinese Med, Sch Clin Med, Kunming 650500, Peoples R China
基金
中国国家自然科学基金;
关键词
nanomaterials; 1; lysosomal; 2; tumor; 3; NEGATIVE BREAST-CANCER; POLY(ADP-RIBOSE) POLYMERASE; MEMBRANE PERMEABILIZATION; MEDICINAL CHEMISTRY; NANOPARTICLES; THERAPY; DELIVERY; DRUG; NANOMEDICINE; INHIBITOR;
D O I
10.3390/cells11213348
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The safety and efficacy of tumor treatment are difficult problems to address. Recently, lysosomes have become an important target for tumor treatment because of their special environment and function. Nanoparticles have unique physicochemical properties which have great advantages in tumor research. Therefore, in recent years, researchers have designed various types of nanoparticles to treat tumors based on lysosomal function and environment. In this review, we summarize and analyze different perspectives of tumor treatment, including direct destruction of lysosomes or lysosomal escape, drug delivery by nanoparticles, response to endogenous or exogenous stimuli, and the targeting of tumor cells or other cells. We describe the advantages and disadvantages of these approaches as well as the developmental prospects in this field. We hope to provide new ideas for better tumor treatment.
引用
收藏
页数:16
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