Efficacy of ketamine intervention to decrease alcohol use, cravings, and withdrawal symptoms in adults with problematic alcohol use or alcohol use disorder: A systematic review and comprehensive analysis of mechanism of actions.

被引：20

作者：

Garel, Nicolas ^{[1
]}

McAnulty, Christina ^{[2
,3
]}

Greenway, Kyle T. ^{[1
]}

Lesperance, Paul ^{[2
,3
]}

Miron, Jean-Philippe ^{[2
,3
]}

Rej, Soham ^{[1
,4
,5
,6
]}

Richard-Devantoy, Stephane ^{[1
,7
]}

Jutras-Aswad, Didier ^{[2
,3
,8
]}

机构：

[1] McGill Univ, Fac Medecine, Dept Psychiat, Ludmer Res & Training Bldg,1033 Ave Pins, Montreal, PQ H3A 1A1, Canada

[2] Ctr Hosp Univ Montreal CRCHUM, Res Ctr, 900 St Denis St, Montreal, PQ H2X 0A9, Canada

[3] Univ Montreal, Fac Med, Dept Psychiat & Addictol, 2900 boul Edouard Montpetit, Montreal, PQ H3T1J4, Canada

[4] Lady Davis Res Inst, McGill Meditat & Mind Body Med Res Clin, Montreal, PQ H3T 1E2, Canada

[5] Lady Davis Res Inst, Geri PARTy Res Grp, Montreal, PQ H3T 1E2, Canada

[6] Jewish Gen Hosp, Montreal, PQ H3T 1E2, Canada

[7] McGill Grp Suicide Studies, Douglas Mental Hlth Res Inst, 6875 Blvd LaSalle, Montreal, PQ H4H 1R3, Canada

[8] CHUM Res Ctr, 900 St Denis St R05 746, Montreal, PQ H2X0A9, Canada

来源：

DRUG AND ALCOHOL DEPENDENCE | 2022年 / 239卷

关键词：

Ketamine; Alcohol use; Withdrawal; Craving; Intervention; Systematic review; RECONSOLIDATION; PSYCHOTHERAPY; ADDICTION; THERAPY; SINGLE;

D O I：

10.1016/j.drugalcdep.2022.109606

中图分类号：

R194 [卫生标准、卫生检查、医药管理];

学科分类号：

摘要：

Background: Alcohol use disorder is highly prevalent and has important economical, societal, psychiatric, and medical consequences. All currently approved therapeutic approaches targeting alcohol dependence have relatively modest effects and high relapse rates. Recent evidence suggests that ketamine may be an effective intervention to treat alcohol use disorder and alcoholic withdrawal. This systematic review aimed to assess the current level of evidence for this intervention. Methods: This systematic review was carried out following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and was registered on the international database of systematic reviews PROSPERO. Medline(Ovid), CINAHL Complete(EBSCOhost), PsycINFO(Ovid), EBM Reviews(Ovid), EMBASE (Ovid), and Google Scholar were searched for studies using ketamine to treat harmful alcohol use, craving, or withdrawal states in humans. Studies of any methodology that evaluated ketamine in isolation or combination with other interventions were included. The risk of bias was assessed using specific Cochrane critical appraisal tools. Results: Of 1922 abstracts identified, 8 full-text articles were eligible for inclusion, yielding a total sample size of 634 participants. Five studies investigated the impact of ketamine on alcohol use and/or cravings and/or withdrawal in outpatient settings. Three studies looked at the effect of adding ketamine to conventional treatment of withdrawal symptoms in participants admitted to intensive care unit for severe alcohol withdrawal. Results on primary outcomes were mixed within and across trials. Conclusions: Despite promising results, the current evidence does not permit definitive conclusions about the efficacy of ketamine in alcohol use disorders or withdrawal. Future studies are warranted.

引用

页数：14

共 56 条

[1]

Anton RF, 1996, ARCH GEN PSYCHIAT, V53, P225

[2] De-duplication of database search results for systematic reviews in EndNote [J].