A 9-gene biomarker panel identifies bacterial coinfections in culture-negative COVID-19 cases

被引：12

作者：

Banerjee, Ushashi ^{[1
]}

Rao, Pragati ^{[2
]}

Reddy, Megha ^{[3
]}

Hussain, Meeran ^{[1
]}

Chunchanur, Sneha ^{[4
]}

Ambica, R. ^{[4
]}

Singh, Amit ^{[5
]}

Chandra, Nagasuma ^{[1
,6
]}

机构：

[1] Indian Inst Sci, Dept Biochem, Bangalore 560012, Karnataka, India

[2] MS Ramaiah Med Coll Hosp, Dept Resp Med, Bangalore, Karnataka, India

[3] MS Ramaiah Med Coll Hosp, Dept Gen Med, Bangalore, Karnataka, India

[4] Bangalore Med Coll & Res Inst BMCRI, Bangalore, Karnataka, India

[5] Indian Inst Sci, Ctr Infect Dis Res, Bangalore, Karnataka, India

[6] Indian Inst Sci, Ctr Biosyst Sci & Engn, Bangalore, Karnataka, India

来源：

MOLECULAR OMICS | 2022年 / 18卷 / 08期

关键词：

PACKAGE;

D O I：

10.1039/d2mo00100d

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Confirmatory diagnosis of bacterial coinfections with COVID-19 is challenging due to the limited specificity of the widely used gold-standard culture sensitivity test despite clinical presentations. A misdiagnosis can either lead to increased health complications or overuse of antibiotics in COVID-19 patients. With a multi-step systems biology pipeline, we have identified a 9-gene biomarker panel from host blood that can identify bacterial coinfection in COVID-19 patients, even in culture-negative cases. We have also formulated a qPCR-based score that diagnoses bacterial coinfection with COVID-19 with the accuracy, specificity, and sensitivity of 0.93, 0.96, and 0.89, respectively. This gene signature and score can assist in the clinical decision-making process of necessary and timely prescription of antibiotics in suspected bacterial coinfection cases with COVID-19 and thereby help to reduce the associated morbidity and mortality.

引用

页码：814 / 820

页数：7

共 19 条

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