T lymphocyte costimulation mediated by reorganization of membrane microdomains

被引：825

作者：

Viola, A ^{[1
]}

Schroeder, S ^{[1
]}

Sakakibara, Y ^{[1
]}

Lanzavecchia, A ^{[1
]}

机构：

[1] Basel Inst Immunol, CH-4005 Basel, Switzerland

来源：

SCIENCE | 1999年 / 283卷 / 5402期

关键词：

D O I：

10.1126/science.283.5402.680

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Although dispensable, costimulation through CD28 facilitates activation of naive T lymphocytes. CD28 engagement Led to the redistribution and clustering of membrane and intracellular kinase-rich raft microdomains at the site of T cell receptor (TCR) engagements. Although not affecting TCR down-regulation, this process Led to higher and more stable tyrosine phosphorylation of several substrates and higher consumption of Lck. These results may provide a general mechanism for amplifying receptor signaling by reorganization of membrane microdomains.

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页码：680 / 682

页数：3

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