Use of Antistaphylococcal β-Lactams to Increase Daptomycin Activity in Eradicating Persistent Bacteremia Due to Methicillin-Resistant Staphylococcus aureus: Role of Enhanced Daptomycin Binding

被引：208

作者：

Dhand, Abhay ^{[1
]}

Bayer, Arnold S. ^{[3
,4
]}

Pogliano, Joseph ^{[5
]}

Yang, Soo-Jin ^{[3
,4
]}

Bolaris, Michael ^{[3
]}

Nizet, Victor ^{[5
]}

Wang, Guiquing ^{[2
]}

Sakoulas, George ^{[1
,5
,6
]}

机构：

[1] New York Med Coll, Div Infect Dis, Dept Med, Valhalla, NY 10595 USA

[2] New York Med Coll, Dept Pathol, Valhalla, NY 10595 USA

[3] Harbor UCLA Med Ctr, LA Biomed Res Inst, Torrance, CA 90509 USA

[4] Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90095 USA

[5] Univ Calif San Diego, Sch Med, La Jolla, CA 92093 USA

[6] Sharp Mem Hosp & Rehabil Ctr, Dept Med, San Diego, CA USA

来源：

CLINICAL INFECTIOUS DISEASES | 2011年 / 53卷 / 02期

关键词：

ANTIBIOTICS; OXACILLIN;

D O I：

10.1093/cid/cir340

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We used daptomycin plus antistaphylococcal beta-lactams (ASBL) to clear refractory MRSA bacteremia. In vitro studies showed enhanced daptomycin bactericidal activity, increased membrane daptomycin binding, and decrease in positive surface charge induced by ASBLs against daptomycin nonsusceptible MRSA. Addition of ASBLs to daptomycin may be of benefit in refractory MRSA bacteremia. (Although the official designation is "daptomycin nonsusceptiblity," we will use the term "daptomycin-resistance" in this paper for facility of presentation.)

引用

页码：158 / 163

页数：6

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