Investigation of Parameters that Affect Resin Swelling in Green Solvents

被引：12

作者：

Amadi-Kamalu, Chidi ^{[1
]}

Clarke, Holly ^{[1
]}

McRobie, Matthew ^{[1
]}

Mortimer, James ^{[1
]}

North, Michael ^{[1
]}

Ran, Yanrui ^{[1
]}

Routledge, Anne ^{[1
]}

Sibbald, Dani ^{[1
]}

Tickias, Matthew ^{[1
]}

Tse, Kai ^{[1
]}

Willway, Helen ^{[1
]}

机构：

[1] Univ York, Dept Chem, York YO10 5DD, N Yorkshire, England

来源：

CHEMISTRYOPEN | 2020年 / 9卷 / 04期

关键词：

polystyrene; solvent; swelling; ChemMatrix; peptide; PHASE PEPTIDE-SYNTHESIS; PERSPECTIVE;

D O I：

10.1002/open.202000030

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The influence of various physical and chemical factors on the swelling of polystyrene and PEG based resins in greener organic solvents has been systematically investigated. In general, chemical factors: the nature of the functionality/linker and the degree of loading were found to have a far larger influence on the swelling of the resins than physical parameters such as bead size. The results are interpreted in terms of Hansen solubility parameters for the solvents and there is evidence that some solvents interact with the polymeric core of a resin whilst others interact with the functionality. The results are extended to a study of the changes in resin swelling observed during both deprotection and chain elongation reactions during solid phase peptide synthesis.

引用

页码：431 / 441

页数：11

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