Effect of estrogen on the expression of galanin mRNA in pituitary tumor-sensitive and tumor-resistant rat strains

被引：5

作者：

Gregg, DW ^{[1
]}

Galkin, M ^{[1
]}

Gorski, J ^{[1
]}

机构：

[1] UNIV WISCONSIN,DEPT BIOCHEM,MADISON,WI 53706

来源：

STEROIDS | 1996年 / 61卷 / 08期

关键词：

galanin; estrogen; pituitary tumor; Fischer; 344; Sprague-Dawley;

D O I：

10.1016/0039-128X(96)00076-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The hypothesis that estrogen-induced pituitary tumors are mediated by the neuropeptide galanin was tested using tumor-resistant (Sprague-Dawley; SD) and tumor-sensitive (Fischer 344; F344) rat strains. Diethylstilbestrol (DES) increased expression of galanin mRNA in both strains after 1, 2, and 4 weeks of treatment and doubled pituitary weights in F344 rats while pituitary weights in SD rats were unchanged by DES treatment. In F344 rats, both the expression of galanin mRNA and pituitary; weights increased linearly with the length of DES treatment. In SD rats however; despite increasing levels of galanin mRNA, pituitary weights did not increase. These delta indicate that galanin gene expression, by itself is not sufficient to account for increased pituitary growth. However, our data do not rule out the possibility that galanin has an indirect role in promoting pituitary growth.

引用

页码：468 / 472

页数：5

共 17 条

[1] SINGLE-STEP METHOD OF RNA ISOLATION BY ACID GUANIDINIUM THIOCYANATE PHENOL CHLOROFORM EXTRACTION [J].