Age-dependent susceptibility of adult hippocampal cell proliferation to chronic psychosocial stress

被引：70

作者：

Simon, M

Czéh, B

Fuchs, E

机构：

[1] Univ Gottingen, German Primate Ctr, Clin Neurobiol Lab, D-37077 Gottingen, Germany

[2] Univ Gottingen, Sch Med, Dept Neurol, D-3400 Gottingen, Germany

来源：

BRAIN RESEARCH | 2005年 / 1049卷 / 02期

关键词：

neurogenesis; BrdU; hippocampus; aging; social stress; tree shrew;

D O I：

10.1016/j.brainres.2005.05.006

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Stress inhibits neurogenesis in the adult dentate gyrus. It is not known, however, whether age has any influence on this process. We subjected adult male tree shrews to 5 weeks of psychosocial stress, after which dentate cytogenesis was determined using BrdU immumohistochemistry. We found that older animals were significantly more vulnerable to the adverse effect of stress on dentate cell proliferation. (c) 2005 Elsevier B.V All rights reserved.

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页码：244 / 248

页数：5

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