Near-infrared spectroscopy study of language activated hyper- and hypo-oxygenation in human prefrontal cortex

被引：11

作者：

Liu, K. Ruth ^{[1
]}

Borrett, Donald S. ^{[2
]}

Cheng, Anita ^{[1
]}

Gasparro, Donna ^{[1
]}

Kwan, Hon C. ^{[1
]}

机构：

[1] Univ Toronto, Dept Physiol, Toronto, ON M5S 1A8, Canada

[2] Toronto E Gen & Orthoped Hosp, Dept Med, Div Neurol, Toronto, ON, Canada

来源：

INTERNATIONAL JOURNAL OF NEUROSCIENCE | 2008年 / 118卷 / 05期

关键词：

language processing; left prefrontal cortex; near-infrared spectroscopy; neuroimaging;

D O I：

10.1080/00207450701242792

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Oxygenation changes in the left prefrontal cortex during language processing were assessed with near-infrared spectroscopy (NIRS). Oxyhemoglobin and deoxyhemoglobin concentrations at the Fp1 site during 5 min of resting with eyes closed (control), followed by 5 min of reading aloud, were monitored. A statistically significant change in the oxyhemoglobin concentration was observed by NIRS in all the subjects after execution of the experimental task. The observations of hyper-oxygenation as well as hypo-oxygenation in the present investigation extend past studies and suggest a complex phenomenon of activation that may be the result of a vascular steal mechanism, attenuated activation baselines, or active cortical deactivation.

引用

页码：657 / 666

页数：10

共 28 条

[1] Human brain language areas identified by functional magnetic resonance imaging [J].

Binder, JR ;

Frost, JA ;

Hammeke, TA ;

Cox, RW ;

Rao, SM ;

Prieto, T .

JOURNAL OF NEUROSCIENCE, 1997, 17 (01) :353-362

[2] Functional MRI of language: New approaches to understanding the cortical organization of semantic processing [J].

Bookheimer, S .

ANNUAL REVIEW OF NEUROSCIENCE, 2002, 25 :151-188

[3] COGNITION-ACTIVATED LOW-FREQUENCY MODULATION OF LIGHT-ABSORPTION IN HUMAN BRAIN [J].

CHANCE, B ;

ZHUANG, Z ;

UNAH, C ;

ALTER, C ;

LIPTON, L .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (08) :3770-3774

[4]

Chee MWL, 1999, J NEUROSCI, V19, P3050

[5] Distinct prefrontal activations in processing sequence at the sentence and script level:: An fMRI study [J].

Crozier, S ;

Sirigu, A ;

Lehéricy, S ;

van de Moortele, PF ;

Pillon, B ;

Grafman, J ;

Agid, Y ;

Dubois, B ;

LeBihan, D .

NEUROPSYCHOLOGIA, 1999, 37 (13) :1469-1476

[6] Form and content: Dissociating syntax and semantics in sentence comprehension [J].

Dapretto, M ;

Bookheimer, SY .

NEURON, 1999, 24 (02) :427-432

[7] Prefrontal hypooxygenation during language processing assessed with near-infrared spectroscopy [J].

Fallgatter, AJ ;

Müller, TJ ;

Strik, WK .

NEUROPSYCHOBIOLOGY, 1998, 37 (04) :215-218

[8] Functional magnetic resonance imaging of semantic memory processes in the frontal lobes [J].

Gabrieli, JDE ;

Desmond, JE ;

Demb, JB ;

Wagner, AD ;

Stone, MV ;

Vaidya, CJ ;

Glover, GH .

PSYCHOLOGICAL SCIENCE, 1996, 7 (05) :278-283

[9] Searching for a baseline: Functional imaging and the resting human brain [J].

Gusnard, DA ;

Raichle, ME .

NATURE REVIEWS NEUROSCIENCE, 2001, 2 (10) :685-694

[10] AGE DEPENDENCY OF CHANGES IN CEREBRAL HEMOGLOBIN OXYGENATION DURING BRAIN ACTIVATION - A NEAR-INFRARED SPECTROSCOPY STUDY [J].

HOCK, C ;

MULLERSPAHN, F ;

SCHUHHOFER, S ;

HOFMANN, M ;

DIRNAGL, U ;

VILLRINGER, A .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 1995, 15 (06) :1103-1108

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