Phosphorylcholine antibodies are diminished in ANCA-associated vasculitis

被引：13

作者：

Wilde, Benjamin ^{[1
,2
]}

Slot, Marjan ^{[1
]}

van Paassen, Pieter ^{[1
]}

Theunissen, Ruud ^{[1
]}

Kemna, Michael ^{[1
,3
]}

Witzke, Oliver ^{[2
]}

Tervaert, Jan Willem Cohen ^{[1
,4
]}

机构：

[1] Maastricht Univ, Clin & Expt Immunol, NL-6202 AZ Maastricht, Netherlands

[2] Univ Duisburg Essen, Univ Hosp Essen, Dept Nephrol, Essen, Germany

[3] Maastricht Univ, Cardiovasc Res Inst Maastricht CARIM, NL-6202 AZ Maastricht, Netherlands

[4] St Franciscus Gasthuis, Rotterdam, Netherlands

来源：

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION | 2015年 / 45卷 / 07期

关键词：

ANCA; OxLDL; PcLDL; vasculitis; OXIDIZED LDL; ATHEROSCLEROSIS;

D O I：

10.1111/eci.12457

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background/AimANCA-associated (AAV) vasculitis is an autoimmune small-vessel vasculitis and may be associated with accelerated atherosclerosis as suggested by current literature. Antibodies against oxidized lipoproteins (OxLDL) and phosphorylcholine (Pc) protect from atherosclerosis. This study characterizes these antibodies in AAV. MethodsPc- and anti-OxLDL antibodies were determined in sera of 39 AAV patients and 44 healthy controls (HC). Intima-media thickness (IMT, carotids) and pulse wave velocity (PWV, A. femoralis) were measured. ResultsPc-/OxLDL IgM antibodies were significantly reduced in AAV. IMT and PWV were negatively associated with anti-Pc antibodies in HC only. ConclusionAtheroprotective anti-Pc/anti-OxLDL antibodies are significantly reduced in AAV possibly explaining accelerated atherosclerosis in vasculitis patients.

引用

页码：686 / 691

页数：6

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