IL-1 family cytokines in cancer immunity - a matter of life and death

被引：23
作者：
Mora, Javier [1 ,2 ]
Weigert, Andreas [1 ]
机构：
[1] Goethe Univ Frankfurt, Fac Med, Inst Biochem 1, Theodor Stern Kai 7, D-60590 Frankfurt, Germany
[2] Univ Costa Rica, Fac Microbiol, San Jose 2060, Costa Rica
来源：
BIOLOGICAL CHEMISTRY | 2016年 / 397卷 / 11期
关键词：
cancer; cell death; cytokines; inflammation; PREDICTS POOR-PROGNOSIS; INHIBITS TUMOR-GROWTH; CD8(+) T-CELLS; HEPATOCELLULAR-CARCINOMA; DECREASED EXPRESSION; ANTITUMOR-ACTIVITY; GASTRIC-CANCER; BREAST-CANCER; NK CELLS; INTERLEUKIN-33;
D O I：
10.1515/hsz-2016-0215
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
IL-1 cytokines constitute a family of biologically active proteins with pleiotropic function especially in immunity. Both protective as well as deleterious properties of individual IL-1 family cytokines in tumor biology have been described. The function of IL-1-family cytokines depends on the producing source, the present (inflammatory) microenvironment and N-terminal proteolytical processing. Each of these determinants is shaped by different modes of cell death. Here we summarize the properties of IL-1 family cytokines in tumor biology, and how they are modulated by cell death.
引用
收藏
页码：1125 / 1134
页数：10
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