IL-1 family cytokines in cancer immunity - a matter of life and death

被引：22

作者：

Mora, Javier ^{[1
,2
]}

Weigert, Andreas ^{[1
]}

机构：

[1] Goethe Univ Frankfurt, Fac Med, Inst Biochem 1, Theodor Stern Kai 7, D-60590 Frankfurt, Germany

[2] Univ Costa Rica, Fac Microbiol, San Jose 2060, Costa Rica

来源：

BIOLOGICAL CHEMISTRY | 2016年 / 397卷 / 11期

关键词：

cancer; cell death; cytokines; inflammation; PREDICTS POOR-PROGNOSIS; INHIBITS TUMOR-GROWTH; CD8(+) T-CELLS; HEPATOCELLULAR-CARCINOMA; DECREASED EXPRESSION; ANTITUMOR-ACTIVITY; GASTRIC-CANCER; BREAST-CANCER; NK CELLS; INTERLEUKIN-33;

D O I：

10.1515/hsz-2016-0215

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

IL-1 cytokines constitute a family of biologically active proteins with pleiotropic function especially in immunity. Both protective as well as deleterious properties of individual IL-1 family cytokines in tumor biology have been described. The function of IL-1-family cytokines depends on the producing source, the present (inflammatory) microenvironment and N-terminal proteolytical processing. Each of these determinants is shaped by different modes of cell death. Here we summarize the properties of IL-1 family cytokines in tumor biology, and how they are modulated by cell death.

引用

页码：1125 / 1134

页数：10

共 50 条

[1] IL-1 family cytokines as drivers and inhibitors of trained immunity
Teufel, Lisa U.
Arts, Rob J. W.
Netea, Mihai G.
Dinarello, Charles A.
Joosten, Leo A. B.
CYTOKINE, 2022, 150
[2] Autophagy and IL-1 family cytokines
Harris, James
FRONTIERS IN IMMUNOLOGY, 2013, 4
[3] Deciphering the crosstalk among IL-1 and IL-10 family cytokines in intestinal immunity
Manzanillo, Paolo
Eidenschenk, Celine
Ouyang, Wenjun
TRENDS IN IMMUNOLOGY, 2015, 36 (08) : 471 - 478
[4] The IL-1 family: regulators of immunity
John E. Sims
Dirk E. Smith
Nature Reviews Immunology, 2010, 10 : 89 - 102
[5] The IL-1 family: regulators of immunity
Sims, John E.
Smith, Dirk E.
NATURE REVIEWS IMMUNOLOGY, 2010, 10 (02) : 89 - 102
[6] IL-1 family cytokines in cardiovascular disease
Pfeiler, Susanne
Winkels, Holger
Kelm, Make
Gerdes, Norbert
CYTOKINE, 2019, 122
[7] The IL-1 family: new and old cytokines
Gabay, Cem
CYTOKINE, 2017, 100 : 45 - 45
[8] A Guide to IL-1 family cytokines in adjuvanticity
Munoz-Wolf, Natalia
Lavelle, Ed C.
FEBS JOURNAL, 2018, 285 (13) : 2377 - 2401
[9] Cytokines in human breast cancer:: IL-1α and IL-1β expression
Kurtzman, SH
Anderson, KH
Wang, YP
Miller, LJ
Renna, M
Stankus, M
Lindquist, RR
Barrows, G
Kreutzer, DL
ONCOLOGY REPORTS, 1999, 6 (01) : 65 - 70
[10] The IL-1 family in tumorigenesis and antitumor immunity
Sun, Runzi
Gao, David Shihong
Shoush, Jason
Lu, Binfeng
SEMINARS IN CANCER BIOLOGY, 2022, 86 : 280 - 295

← 1 2 3 4 5 →