Natural killer cells and autoimmunity

被引：94
作者：
French, AR
Yokoyama, WM
机构：
[1] Washington Univ, Sch Med, Howard Hughes Med Inst, Dept Med,Div Rheumatol, St Louis, MO 63110 USA
[2] Washington Univ, Sch Med, Dept Pediat, Div Pediat Rheumatol, St Louis, MO 63110 USA
来源：
ARTHRITIS RESEARCH & THERAPY | 2004年 / 6卷 / 01期
关键词：
autoimmunity; immunoregulation; natural killer cells;
D O I：
10.1186/ar1034
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Autoimmune diseases are often characterized as clinical syndromes caused by the inappropriate activation of T or B cells resulting in systemic or organ-specific damage. However, studies support a role for the innate immune system, and in particular natural killer (NK) cells, in stimulating or suppressing autoimmunity. This review focuses on recent research elucidating a potential immunoregulatory role for NK cells in modulating T and B cell-mediated autoimmunity.
引用
收藏
页码：8 / 14
页数：7
相关论文
共 89 条
[21]   The natural killer cell -: Friend or foe in autoimmune disease? [J].
Flodström, M ;
Shi, FD ;
Sarvetnick, N ;
Ljunggren, HG .
SCANDINAVIAN JOURNAL OF IMMUNOLOGY, 2002, 55 (05) :432-441
[22]   Target cell defense prevents the development of diabetes after viral infection [J].
Flodström, M ;
Maday, A ;
Balakrishna, D ;
Cleary, MM ;
Yoshimura, A ;
Sarvetnick, N .
NATURE IMMUNOLOGY, 2002, 3 (04) :373-382
[23]  
Fort MM, 1998, J IMMUNOL, V161, P3256
[24]   Natural killer cells and viral infections [J].
French, AR ;
Yokoyama, WM .
CURRENT OPINION IN IMMUNOLOGY, 2003, 15 (01) :45-51
[25]   Can virus infections trigger autoimmune disease? [J].
Fujinami, RS .
JOURNAL OF AUTOIMMUNITY, 2001, 16 (03) :229-234
[26]   Reciprocal activating interaction between natural killer cells and dendritic cells [J].
Gerosa, F ;
Baldani-Guerra, B ;
Nisii, C ;
Marchesini, V ;
Carra, G ;
Trinchieri, G .
JOURNAL OF EXPERIMENTAL MEDICINE, 2002, 195 (03) :327-333
[27]   Stimulation of T cell autoreactivity by anomalous expression of NKG2D and its MIC ligands in rhe'umatoid arthritis [J].
Groh, V ;
Brühl, A ;
El-Gabalawy, H ;
Nelson, JL ;
Spies, T .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (16) :9452-9457
[28]   Costimulation of CD8αβ T cells by NKG2D via engagement by MIC induced on virus-infected cells [J].
Groh, V ;
Rhinehart, R ;
Randolph-Habecker, J ;
Topp, MS ;
Riddell, SR ;
Spies, T .
NATURE IMMUNOLOGY, 2001, 2 (03) :255-260
[29]   Natural killer cell dysfunction in patients with systemic-onset juvenile rheumatoid arthritis and macrophage activation syndrome [J].
Grom, AA ;
Villanueva, J ;
Lee, S ;
Goldmuntz, EA ;
Passo, MH ;
Filipovich, A .
JOURNAL OF PEDIATRICS, 2003, 142 (03) :292-296
[30]   NATURAL-KILLER CELLS AND AUTOIMMUNITY [J].
GRUNEBAUM, E ;
MALATZKYGOSHEN, E ;
SHOENFELD, Y .
IMMUNOLOGIC RESEARCH, 1989, 8 (04) :292-304
123456789