Natural killer cells and autoimmunity

被引：94
作者：
French, AR
Yokoyama, WM
机构：
[1] Washington Univ, Sch Med, Howard Hughes Med Inst, Dept Med,Div Rheumatol, St Louis, MO 63110 USA
[2] Washington Univ, Sch Med, Dept Pediat, Div Pediat Rheumatol, St Louis, MO 63110 USA
来源：
ARTHRITIS RESEARCH & THERAPY | 2004年 / 6卷 / 01期
关键词：
autoimmunity; immunoregulation; natural killer cells;
D O I：
10.1186/ar1034
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Autoimmune diseases are often characterized as clinical syndromes caused by the inappropriate activation of T or B cells resulting in systemic or organ-specific damage. However, studies support a role for the innate immune system, and in particular natural killer (NK) cells, in stimulating or suppressing autoimmunity. This review focuses on recent research elucidating a potential immunoregulatory role for NK cells in modulating T and B cell-mediated autoimmunity.
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收藏
页码：8 / 14
页数：7
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