Equivocal evidence of complete carcinogenicity after repeated infection of Syrian hamsters with Opisthorchis viverrini

被引:12
作者
Thamavit, W [1 ]
Tiwawech, D [1 ]
Moore, MA [1 ]
Ito, N [1 ]
Shirai, T [1 ]
机构
[1] NAGOYA CITY UNIV,SCH MED,DEPT PATHOL 1,MIZUHO KU,NAGOYA,AICHI 467,JAPAN
关键词
opisthorchiasis; liver cancer; proliferation; inflammation;
D O I
10.1177/019262339602400412
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
The effects of repeated infection with Opisthorchis viverrini on liver lesion development in male and female Syrian hamsters were investigated over a 1-yr period. Ten monthly intragastric applications of 50, 25, 13, or 0 parasite metacercariae resulted in pronounced proliferative and inflammatory lesions involving the first- and second-order ducts in response to the presence of adult worms. Despite the development of small numbers of putative preneoplastic areas of cholangiofibrosis and morphologically altered hepatocellular foci, no neoplastic lesions were evident at sacrifice after 1 yr. The results thus suggest that parasite infestation is itself not strongly carcinogenic if at all but, rather, that it exerts a marked promoting influence on cholangiocellular and hepatocellular tumor development in the hamster via chronic irritation and increased cell turnover.
引用
收藏
页码:493 / 497
页数:5
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