Identification and characterization of the new designer drug 4′-methylethcathinone (4-MEC) and elaboration of a novel liquid chromatography-tandem mass spectrometry (LC-MS/MS) screening method for seven different methcathinone analogs

被引：66

作者：

Jankovics, Peter ^{[1
]}

Varadi, Andras ^{[2
]}

Toelgyesi, Laszlo ^{[3
,4
]}

Lohner, Szilvia ^{[1
]}

Nemeth-Palotas, Julia ^{[1
]}

Koszegi-Szalai, Hilda ^{[1
]}

机构：

[1] Natl Inst Pharm, H-1051 Budapest, Hungary

[2] Semmelweis Univ, Dept Pharmaceut Chem, H-1092 Budapest, Hungary

[3] Eotvos Lorand Univ, Joint Res & Training Lab Separat Tech, H-1117 Budapest, Hungary

[4] Kromat Ltd Co, H-1112 Budapest, Hungary

来源：

FORENSIC SCIENCE INTERNATIONAL | 2011年 / 210卷 / 1-3期

关键词：

4 '-Methylethcathinone (4-MEC); Methcathinone derivatives; LC-MS; NMR; FT-IR spectroscopy; MEPHEDRONE; METHYLONE; 4-METHYLMETHCATHINONE; METABOLISM;

D O I：

10.1016/j.forsciint.2011.03.019

中图分类号：

DF [法律]; D9 [法律]; R [医药、卫生];

学科分类号：

0301 ; 10 ;

摘要：

A fast and simple LC-MS/MS method was developed for screening mephedrone, butylone, methylenedioxypyrovalerone (MDPV), flephedrone, methylone and methedrone in bulk powder samples. Samples were separated on a reverse phase column using gradient elution with mixtures of water, acetonitrile and formic acid. After optimization a limit of detection of about 2 ng mL (1) was achieved using multiple reaction monitoring (MRM) mode. Total run time was less than 8 min. Typical fragmentation characteristics of the studied compounds are discussed. The method was successfully applied to several unknown bulk powder samples seized by the Hungarian Customs and Finance Guard. One of the samples contained the new designer drug 4'-methylethcathinone (4-MEC), which was identified and characterized by LC-MS/MS, NMR, FT-IR and LC-TOF-MS techniques. The method is also deemed to be applicable for the screening of simple dosage forms such as tablets and capsules.

引用

页码：213 / 220

页数：8

共 26 条

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