Lindenane Disesquiterpenoids with Anti-HIV-1 Activity from Chloranthus japonicus

被引：86

作者：

Fang, Ping-Lei ^{[3
,4
]}

Cao, Ying-Li ^{[1
,2
]}

Yan, Huan ^{[3
]}

Pan, Li-Li ^{[3
,4
]}

Liu, Shu-Cong ^{[1
,2
]}

Gong, Ning-Bo ^{[1
,2
]}

Lue, Yang ^{[1
,2
]}

Chen, Chang-Xiang ^{[3
]}

Zhong, Hui-Min ^{[4
]}

Guo, Ying ^{[1
,2
]}

Liu, Hai-Yang ^{[3
]}

机构：

[1] Chinese Acad Med Sci, Inst Mat Med, Dept Pharmacol, Beijing 100050, Peoples R China

[2] Peking Union Med Coll, Beijing 100050, Peoples R China

[3] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China

[4] Qingdao Univ Sci & Technol, Coll Chem & Mol Engn, Qingdao 266042, Peoples R China

来源：

JOURNAL OF NATURAL PRODUCTS | 2011年 / 74卷 / 06期

关键词：

CHEMICAL-CONSTITUENTS; SESQUITERPENE DIMER; PLANTS;

D O I：

10.1021/np200087d

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Five new lindenane disesquiterpenoids, chlorajaponilides A-E (1-5), together with 11 known analogues were isolated from whole plants of Chloranthus japonicus. The structure and absolute configuration of 1 was confirmed by X-ray crystallography. Compounds 1 and 2 represent the first examples of lindenane disesquiterpenoids with a C-5 hydroxy group and a C-4- C-15 double bond. Compounds 8, 9, 11, and 12 showed anti-HIV-1 replication activities in both wild-type HIV-1 and two NNRTIs-resistant strains. Shizukaol B (8) exhibited the best activity against HWwt, HIVRT-K103N, and HIVRT-K103N with EC50 values of 0.22, 0.47, and 0.50, mu M, respectively. Compounds 8, 9, 11, and 12 had significant cytotoxicities against C8166 cells with CC50 values of 0.020, 0.089, 0.047, and 0.022, respectively, and exhibited inhibitory activities against HIV-I with EC50 values of 0.0014, 0.016, 0.0043, and 0.0033,mu M, respectively.

引用

页码：1408 / 1413

页数：6

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