Capture and light-induced release of antibiotics by an azo dye polymer

被引:5
|
作者
Atkins, Stephen [1 ]
Chueh, Alysa [2 ]
Barwell, Taylor [1 ]
Nunzi, Jean-Michel [2 ,3 ]
Seroude, Laurent [1 ]
机构
[1] Queens Univ, Dept Biol, Kingston, ON K7L 3N6, Canada
[2] Queens Univ, Dept Chem, Kingston, ON K7L 3N6, Canada
[3] Queens Univ, Dept Phys Engn Phys & Astron, Kingston, ON K7L 3N6, Canada
基金
加拿大自然科学与工程研究理事会;
关键词
RESISTANCE; DISPERSE; GLASS;
D O I
10.1038/s41598-020-60245-6
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The isomerisation of azo dyes can induce conformational changes which have potential applications in medicine and environmental protection. We developed an agar diffusion assay to test the capture and release of biologically active molecules from an azo electro-optic polymer, Poly (Disperse Red 1 methacrylate) (DR1/PMMA). The assay monitors the growth of bacteria placed in soft agar under a glass coverslip. Antibiotics can then be applied on the coverslip resulting in the clearance of the area under the coverslip due to growth inhibition. This assay demonstrates that DR1/PMMA is able to capture either tetracycline or ampicillin and the relative amount of DR1/PMMA required for capture was determined. Finally, the active antibiotics can be released from DR1/PMMA by exposure to green laser light. Exposure to white light from a torch or to heat does not release the antibiotic.
引用
收藏
页数:6
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