Alzheimer's disease shares gene expression aberrations with purinergic dysregulation of HPRT deficiency (Lesch-Nyhan disease)

被引：14

作者：

Kang, Tae Hyuk ^{[1
]}

Friedmann, Theodore ^{[2
]}

机构：

[1] Yale Univ, Sch Med, Dept Neurol, New Haven, CT 06511 USA

[2] Univ Calif San Diego, Sch Med, Dept Pediat, La Jolla, CA 92093 USA

来源：

NEUROSCIENCE LETTERS | 2015年 / 590卷

基金：

美国国家卫生研究院;

关键词：

Neurogenesis; Neurodevelopment disease; Neurodegenerative disease; Alzheimer's disease; HPRT; Lesch-Nyhan disease; NEURONAL DIFFERENTIATION; RECEPTORS; GROWTH; NUCLEOTIDE; PATHWAYS; ACTIVATION; COMPLEX; PROTEIN; MODEL;

D O I：

10.1016/j.neulet.2015.01.042

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Transcriptomic studies of murine D3 embryonic stem (ES) cells deficient in the purinergic biosynthetic function hypoxanthine guanine phosphoribosyltransferase (HPRT) and undergoing dopaminergic neuronal differentiation has demonstrated a marked shift from neuronal to glial gene expression and aberrant expression of multiple genes also known to be aberrantly expressed in Alzheimer's and other CNS disorders. Such genetic dysregulations may indicate some shared pathogenic metabolic mechanisms in diverse CNS diseases. (C) 2015 Elsevier Ireland Ltd. All rights reserved.

引用

页码：35 / 39

页数：5

共 50 条

[41] Dysregulation of antimicrobial peptide expression distinguishes Alzheimer's disease from normal aging
Wang, Min
Peng, I-Feng
Li, Simin
Hu, Xianda
AGING-US, 2020, 12 (01): : 690 - 706
[42] Gene expression meta-analysis of Parkinson’s disease and its relationship with Alzheimer’s disease
Jack Kelly
Rana Moyeed
Camille Carroll
Diego Albani
Xinzhong Li
Molecular Brain, 12
[43] Theobromine-Induced Changes in A1 Purinergic Receptor Gene Expression and Distribution in a Rat Brain Alzheimer's Disease Model
Mendiola-Precoma, Jesus
Padilla, Karla
Rodriguez-Cruz, Alfredo
Berumen, Laura C.
Miledi, Ricardo
Garcia-Alcocer, Guadalupe
JOURNAL OF ALZHEIMERS DISEASE, 2017, 55 (03) : 1273 - 1283
[44] Gene Ontology Curation of Neuroinflammation Biology Improves the Interpretation of Alzheimer's Disease Gene Expression Data
Kramarz, Barbara
Huntley, Rachael P.
Rodriguez-Lopez, Milagros
Roncaglia, Paola
Saverimuttu, Shirin C. C.
Parkinson, Helen
Bandopadhyay, Rina
Martin, Maria-Jesus
Orchard, Sandra
Hooper, Nigel M.
Brough, David
Lovering, Ruth C.
JOURNAL OF ALZHEIMERS DISEASE, 2020, 75 (04) : 1417 - 1435
[45] Metals toxicity and its correlation with the gene expression in Alzheimer's disease
Yadav, Jyoti
Verma, Anoop Kumar
Ahmad, Md. Kaleem
Garg, Ravindra K.
Shiuli
Mahdi, Abbas Ali
Srivastava, Shrikant
MOLECULAR BIOLOGY REPORTS, 2021, 48 (04) : 3245 - 3252
[46] Gene expression profiles of metabolic enzyme transcripts in Alzheimer's disease
Brooks, Wendy M.
Lynch, Patrick J.
Ingle, Catherine C.
Hatton, Alexander
Emson, Piers C.
Faull, Richard L. M.
Starkey, Mike P.
BRAIN RESEARCH, 2007, 1127 (01) : 127 - 135
[47] Single molecule profiling of tau gene expression in Alzheimer's disease
Conrad, Chris
Zhu, Jun
Conrad, Cintia
Schoenfeld, David
Fang, Zhide
Ingelsson, Martin
Stamm, Stefan
Church, George
Hyman, Bradley T.
JOURNAL OF NEUROCHEMISTRY, 2007, 103 (03) : 1228 - 1236
[48] Striatal expression of glutamic acid decarboxylase gene in Alzheimer's disease
Boissière, F
Faucheux, B
Duyckaerts, C
Hauw, JJ
Agid, Y
Hirsch, EC
JOURNAL OF NEUROCHEMISTRY, 1998, 71 (02) : 767 - 774
[49] Integrating Gene Expression and Phenotypic Information to Analyze Alzheimer's Disease
Ray, Monika
Zhang, Weixiong
JOURNAL OF ALZHEIMERS DISEASE, 2009, 16 (01) : 73 - 84
[50] A Gene Expression Pattern in Blood for the Early Detection of Alzheimer's Disease
Booij, Birgitte Boonstra
Lindahl, Torbjorn
Wetterberg, Peter
Skaane, Nina Voss
Saebo, Solve
Feten, Guri
Rye, Phil D.
Kristiansen, Lena Iren
Hagen, Nina
Jensen, Marianne
Bardsen, Ken
Winblad, Bengt
Sharma, Praveen
Lonneborg, Anders
JOURNAL OF ALZHEIMERS DISEASE, 2011, 23 (01) : 109 - 119

← 1 2 3 4 5 →