Sildenafil (VIAGRA(TM)), a potent and selective inhibitor of type 5 cGMP phosphodiesterase with utility for the treatment of male erectile dysfunction

被引：580

作者：

Terrett, NK ^{[1
]}

Bell, AS ^{[1
]}

Brown, D ^{[1
]}

Ellis, P ^{[1
]}

机构：

[1] PFIZER LTD,CENT RES,DEPT DISCOVERY BIOL,SANDWICH CT13 9NJ,KENT,ENGLAND

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 15期

关键词：

D O I：

10.1016/0960-894X(96)00323-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

5-(2'-Alkoxyphenyl)pyrazolo[4,3-d]pyrimidin-7-ones, and in particular our preferred compound, sildenafil (VIAGRA(TM)), discovered through a rational drug design programme, are potent and selective inhibitors of the type 5 cGMP phosphodiesterase from both rabbit platelets and human corpus cavernosum. Sildenafil is currently in the clinic for the oral treatment of male erectile dysfunction. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：1819 / 1824

页数：6

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