Composition and Variation of the Human Milk Microbiota Are Influenced by Maternal and Early-Life Factors

被引：383

作者：

Moossavi, Shirin ^{[1
,2
,3
,4
]}

Sepehri, Shadi ^{[2
]}

Robertson, Bianca ^{[5
]}

Bode, Lars ^{[5
,6
]}

Goruk, Sue ^{[7
]}

Field, Catherine J. ^{[7
]}

Lix, Lisa M. ^{[8
]}

de Souza, Russell J. ^{[9
,10
,11
]}

Becker, Allan B. ^{[2
,3
]}

Mandhane, Piushkumar J. ^{[12
]}

Turvey, Stuart E. ^{[13
]}

Subbarao, Padmaja ^{[14
,15
]}

Moraes, Theo J. ^{[14
]}

Lefebvre, Diana L. ^{[16
]}

Sears, Malcolm R. ^{[16
]}

Khafipour, Ehsan ^{[2
,17
]}

Azad, Meghan B. ^{[2
,3
]}

机构：

[1] Univ Manitoba, Med Microbiol & Infect Dis, Winnipeg, MB, Canada

[2] Childrens Hosp Res Inst Manitoba, Pediat & Child Hlth, Winnipeg, MB, Canada

[3] Dev Origins Chron Dis Children Network DEVOTION, Winnipeg, MB, Canada

[4] Univ Tehran Med Sci, Digest Dis Res Inst, Digest Oncol Res Ctr, Tehran, Iran

[5] Univ Calif San Diego, Pediat, La Jolla, CA 92093 USA

[6] Univ Calif San Diego, Mother Milk Infant Ctr Res Excellence, Larsson Rosenquist Fdn, La Jolla, CA 92093 USA

[7] Univ Alberta, Agr Food & Nutr Sci, Edmonton, AB, Canada

[8] Univ Manitoba, Community Hlth Sci, Winnipeg, MB, Canada

[9] McMaster Univ, Clin Epidemiol & Biostat, Hamilton, ON, Canada

[10] Univ Toronto, Nutr Sci, Toronto, ON, Canada

[11] St Michaels Hosp, Li Ka Shing Knowledge Inst, Toronto, ON, Canada

[12] Univ Alberta, Pediat, Edmonton, AB, Canada

[13] Univ British Columbia, Pediat, Vancouver, BC, Canada

[14] Univ Toronto, Hosp Sick Children, Div Resp Med, Pediat, Toronto, ON, Canada

[15] Univ Toronto, Physiol, Toronto, ON, Canada

[16] McMaster Univ, Med, Hamilton, ON, Canada

[17] Univ Manitoba, Anim Sci, Winnipeg, MB, Canada

来源：

CELL HOST & MICROBE | 2019年 / 25卷 / 02期

基金：

加拿大自然科学与工程研究理事会; 加拿大健康研究院;

关键词：

INFANT BODY-COMPOSITION; GUT MICROBIOTA; BREAST-MILK; R PACKAGE; MULTIVARIATE IMPUTATION; MOTHERS MILK; 1ST YEAR; ASSOCIATIONS; OLIGOSACCHARIDES; COMMUNITIES;

D O I：

10.1016/j.chom.2019.01.011

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Breastmilk contains a complex community of bacteria that may help seed the infant gut microbiota. The composition and determinants of milk microbiota are poorly understood. Among 393 mother-infant dyads from the CHILD cohort, we found that milk microbiota at 3-4 months postpartum was dominated by inversely correlated Proteobacteria and Firmicutes, and exhibited discrete compositional patterns. Milk microbiota composition and diversity were associated with maternal factors (BMI, parity, and mode of delivery), breastfeeding practices, and other milk components in a sex-specific manner. Causal modeling identified mode of breastfeeding as a key determinant of milk microbiota composition. Specifically, providing pumped breastmilk was consistently associated with multiple microbiota parameters including enrichment of potential pathogens and depletion of bifidobacteria. Further, these data support the retrograde inoculation hypothesis, whereby the infant oral cavity impacts the milk microbiota. Collectively, these results identify features and determinants of human milk microbiota composition, with potential implications for infant health and development.

引用

页码：324 / +

页数：16

共 70 条

[1] Associations between human milk oligosaccharides and infant body composition in the first 6 mo of life [J].